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Table 1 Differential expression of mRNA from methamphetamine self-administration rats

From: mRNA and microRNA analysis reveals modulation of biochemical pathways related to addiction in the ventral tegmental area of methamphetamine self-administering rats

Gene name Fold change (log2) p-value miRNA targeta
Upregulated
 Endosomes
  Slc9a6 −0.51 0.0025 miR-181a/d, 16, 195, 124
  Mtpn −1.00 0.0028 miR-124, 9, 181, 140, 143, 26a, let-7
  Myo18b −0.53 0.0049  
 Cell signaling
  Ankh −0.56 9.30E−05 miR-9
  Ppm1h −0.56 0.00087 miR-125a-5p/b-5p, 351
  Gpr64 −0.60 0.0012 miR-23a/b
  Cd47 −0.52 0.0016 miR-181d, 9
 Neurite growth/extension
  Ntn1 −0.75 0.0010 let-7d/e, miR-27a/b, 20a, 106b
  LOC691277 −0.52 0.0040  
 Neuroprotection
  Pex3 −0.64 0.00052 miR-30b-5p/c/d
  Coa5/6330578E17Rik −0.87 0.00024  
  Ret −0.88 0.0023 miR-23a/b, 128, 27a/b, 125a-5p/b-5p
  Hsp90ab1 −0.82 0.0030  
 RNA processing
  Hnrnpa3 −0.62 0.00034 miR-221, 222, 206
  Rpp30 −0.55 0.0022  
  Rpl19 −0.94 0.0037  
  LOC100359671 −0.55 0.0049  
 Membrane transporters/receptors
  Olr527 −1.05 0.00040  
  Slc6a3 −2.45 0.0010  
  RGD1561777 −0.82 0.0014  
  Mc3r −1.03 0.0030  
  Tacr3/Nk3R −0.83 0.0031  
  Chrna6 −1.76 0.0045  
  Slc47a2 −0.51 0.0047  
 Transcriptional regulation
  Foxa1/HNF3-alpha −0.78 0.00054 miR-106b, 194, 30b-5p/c, 20a
  Mir181a-2 −0.69 0.00085  
  LOC690309 −0.78 0.0012 miR-26a, 29a/b/c, 222, 383
  Pfdn1 −0.67 0.0014  
  Smg6 −0.51 0.0029  
 Other
  Cry1 −0.58 0.0010  
  Samd9 l −0.69 0.0038  
Downregulated
 Endosomes
  Dnah3 0.63 0.00021  
  Lin7a/MALS-1 0.64 0.00043  
  LOC494539 0.51 0.0029 miR-125a-5p
  Ifitm7 0.72 0.0039  
 Cell signaling
  Dkk3 0.66 0.0011 let-7
  Gtpbp4 0.78 0.0012  
 Membrane transporters/receptors
  Olr625 0.64 0.00048  
  Vom1r2 0.69 0.0018  
  Vom1r26 0.93 0.0022  
  Olr1373 0.63 0.0033  
 Transcriptional regulation
  Naca 0.57 0.00066  
 Other
  LOC690000 0.53 0.00096  
  LOC691519 0.50 0.0018  
  LOC691988 0.84 0.0029  
  Senp17 1.34 0.0029  
  Apol3 1.14 0.0031  
  XTP2 0.90 0.0046  
Canonical pathwayb mRNA p-value RER
Ribosome biogenesis in eukaryotes Rpp30, Gtpbp4 0.0024 27.45
Neuroactive ligand-receptor interaction Tacr3, Chrna6, Mc3r 0.0019 12.27
RNA transport Rpp30, Senp17 0.0081 14.78
Pathways in cancer Hsp90ab1, Ret 0.0313 7.23
  1. RER ratio of enrichment.
  2. aListed are miRNA transcripts significantly differentially expressed in the microarray experiment.
  3. bDetermined using WebGestalt.
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BMC Neuroscience

ISSN: 1471-2202

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