Effect of AMPK inhibitor Comp c, peroxynitrite scavenger FeTPPS and AMPK activator AICAR on infarct volume and neurological score. Infarct volume (a calculated from TTC stained sections) and neurological score (b) at 24 h of IR. While Comp c, FeTPPS and AICAR were administered 1 h, GSNO was administered 0 h after reperfusion began. Data are presented as mean ± SD (n = 5). ***p < 0.001 vs. IR, $$$p < 0.001 vs. AICAR, +++p < 0.001 vs. GSNO.