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Figure 1 | BMC Neuroscience

Figure 1

From: Differential effects of antidepressants escitalopram versus lithium on Gs alpha membrane relocalization

Figure 1

Gsα is removed from lipid rafts subsequent to antidepressant treatment while lithium has the opposite effect. Cells were treated as indicated in “Methods” and lipid rafts were isolated using sucrose gradient flotation. The amount of Gsα was determined by Western blot. a The figure shows the percentage of change in Gsα protein compared to control in the lipid raft membrane fractions (n = 7 for control, escitalopram and lithium; n = 5 for valproic acid). Data were analyzed by one-way ANOVA (p < 0.0006) followed by Tukey’s multiple comparison test for post hoc comparison of means. Data are represented as mean ± SEM (**, p < 0.005 compared to escitalopram). b A representative immunoblot of lipid raft Gsα from the various treatment paradigms as explained in “Methods”. C control, E escitalopram, L lithium, V valproic acid.

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