Figure 1From: Bioenergetics of the spinal cord in experimental autoimmune encephalitis of ratsDA rats develop EAE while AO rats are resistant. DA (b–d) developed severe EAE whilst AO rats did not (a). Rats were immunized with MBP in complete Freund adjuvant. a, c Low magnification micrographs of sections of the spinal cord of AO and DA rats respectively; b, d high magnification micrographs of spinal cord sections of DA rats examined 14 days after immunization using H&E staining. Note the presence of typical perivascular and subpial infiltrates of different sizes in areas of the spinal cords of DA rats (b, d). g Clinical scores show that DA rats become severely diseased with time, whereas AO rats do not develop the disease. Results are mean clinical scores ± SEM (n = 5, representative of four experiments, p < 0.001). h A cumulative graph of semiquantitative assessment of the histological score of disease from the spinal cords of DA and AO rats of 10 noncontiguous sections per spinal cord (p < 0.001, n = 3). e Micrographs of Luxol fast blue-stained sections of the spinal cord of immunized DA rats at peak of disease (n = 5). The dorsal column (square box) of the DA rat is enlarged in f to show areas of infiltration around which there seem to be evidence of demyelination (arrows). Bar 20 μm.Back to article page