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Figure 1 | BMC Neuroscience

Figure 1

From: Bioenergetics of the spinal cord in experimental autoimmune encephalitis of rats

Figure 1

DA rats develop EAE while AO rats are resistant. DA (b–d) developed severe EAE whilst AO rats did not (a). Rats were immunized with MBP in complete Freund adjuvant. a, c Low magnification micrographs of sections of the spinal cord of AO and DA rats respectively; b, d high magnification micrographs of spinal cord sections of DA rats examined 14 days after immunization using H&E staining. Note the presence of typical perivascular and subpial infiltrates of different sizes in areas of the spinal cords of DA rats (b, d). g Clinical scores show that DA rats become severely diseased with time, whereas AO rats do not develop the disease. Results are mean clinical scores ± SEM (n = 5, representative of four experiments, p < 0.001). h A cumulative graph of semiquantitative assessment of the histological score of disease from the spinal cords of DA and AO rats of 10 noncontiguous sections per spinal cord (p < 0.001, n = 3). e Micrographs of Luxol fast blue-stained sections of the spinal cord of immunized DA rats at peak of disease (n = 5). The dorsal column (square box) of the DA rat is enlarged in f to show areas of infiltration around which there seem to be evidence of demyelination (arrows). Bar 20 μm.

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