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Figure 6 | BMC Neuroscience

Figure 6

From: Targeted inhibition of the Shroom3–Rho kinase protein–protein interaction circumvents Nogo66 to promote axon outgrowth

Figure 6

CCG-17444 enhances neurite outgrowth in CGNs and counteracts the inhibitory action of Nogo66. Postnatal d8 CGNs were treated for 24 h with CCG-17444, vehicle control, or the ROCK inhibitor Y27632 (positive control). a Nogo66 inhibits neurite outgrowth in CGNs, and CCG-17444 counteracts this inhibition. Scale bar 100 μm. b Quantitation of neurite length. Data are mean ± SD (n = 3, *p < 0.0001, Student’s t test).

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BMC Neuroscience

ISSN: 1471-2202

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