Skip to main content
Figure 1 | BMC Neuroscience

Figure 1

From: Targeted inhibition of the Shroom3–Rho kinase protein–protein interaction circumvents Nogo66 to promote axon outgrowth

Figure 1

Shroom3 and Rho kinase interact with high affinity. a A schematic overview of the Shroom3 and ROCK II domain architecture. R2C1 is the Shroom binding domain (SBD) of ROCK II. Shroom domain (SD) 2 is the ROCK interacting domain of Shroom3. In these studies, R2C1 and SD2 encode amino acids 698–957 and 1,563–1,986 of ROCK II and Shroom3, respectively. b Shroom3 and ROCK II interact with nM affinity (Kd ± SEM, n = 8). c Unlabeled R2C1 competes with biotin labeled R2C1 for association with SD2 in a dose dependent manner (n = 4, *p < 0.05, Student’s t test).

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us