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Fig. 2 | BMC Neuroscience

Fig. 2

From: A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs

Fig. 2

Human and cat TAS2R38 show different ligand responses and affinities. Cells were transiently transfected with Gα16-gust44 and the indicated receptors human TAS2R38 (H38) TAS2R43 (H43) and TAS2R16 (H16), and cat Tas2r38 (C38) and Tas2r43 (C43). 22 hours post-transfection, calcium influx was measured in cells challenged with the ligands characteristic for human TAS2R38. (a & b) Both human and cat TAS2R38 responded to PTC in a dose-dependent manner (individual trace shown for 100 μM); however, the dose response shows the cat Tas2r38 EC50 (47 μM) was at least 10-fold lower than that of human TAS2R38 (2.3 μM). (c & d) Only human TAS2R38 responded to PROP. (e) Both human and cat TAS2R38 responded to C4-HSL

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BMC Neuroscience

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