TY - CHAP AU - Yamori, Y. ED - Jong, W. D. PY - 1984 DA - 1984// TI - Development of the Spontaneously Hypertensive Rat (SHR) and of Various Spontaneous Rat Models, and Their Implications BT - In Experimental and Genetic Models of Hypertension. Volume 4 PB - Elsevier CY - New York ID - Yamori1984 ER - TY - JOUR AU - Yamori, Y. AU - Horie, R. AU - Handa, H. AU - Sato, M. AU - Fukase, M. PY - 1976 DA - 1976// TI - Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans JO - Stroke VL - 7 UR - https://doi.org/10.1161/01.STR.7.1.46 DO - 10.1161/01.STR.7.1.46 ID - Yamori1976 ER - TY - JOUR AU - Okamoto, K. AU - Yamori, Y. AU - Nagaoka, A. PY - 1974 DA - 1974// TI - Establishment of the stroke-prone spontaneously hypertensive rat (SHR) JO - Circ Res VL - 33/34 ID - Okamoto1974 ER - TY - JOUR AU - Fredriksson, K. AU - Kalimo, H. AU - Westergren, I. AU - Kåhrström, J. AU - Johansson, B. B. PY - 1987 DA - 1987// TI - Blood–brain barrier leakage and brain edema in stroke-prone spontaneously hypertensive rats. Effect of chronic sympathectomy and low protein/high salt diet JO - Acta Neuropathol VL - 74 UR - https://doi.org/10.1007/BF00688190 DO - 10.1007/BF00688190 ID - Fredriksson1987 ER - TY - JOUR AU - Lee, J. M. AU - Zhai, G. AU - Liu, Q. AU - Gonzales, E. R. AU - Yin, K. AU - Yan, P. PY - 2007 DA - 2007// TI - Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats JO - Stroke VL - 38 UR - https://doi.org/10.1161/STROKEAHA.107.491621 DO - 10.1161/STROKEAHA.107.491621 ID - Lee2007 ER - TY - JOUR AU - Schreiber, S. AU - Bueche, C. Z. AU - Garz, C. AU - Braun, H. PY - 2013 DA - 2013// TI - Blood brain barrier breakdown as the starting point of cerebral small vessel disease? - New insights from a rat model JO - Exp Transl Stroke Med VL - 5 UR - https://doi.org/10.1186/2040-7378-5-4 DO - 10.1186/2040-7378-5-4 ID - Schreiber2013 ER - TY - JOUR AU - Ueno, M. AU - Sakamoto, H. AU - Tomimoto, H. AU - Akiguchi, I. AU - Onodera, M. AU - Huang, C. L. PY - 2004 DA - 2004// TI - Blood–brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats JO - Acta Neuropathol VL - 107 UR - https://doi.org/10.1007/s00401-004-0845-z DO - 10.1007/s00401-004-0845-z ID - Ueno2004 ER - TY - JOUR AU - Negishi, H. AU - Ikeda, K. AU - Sagara, M. AU - Sawamura, M. AU - Yamori, Y. PY - 1999 DA - 1999// TI - Increased oxidative DNA damage in stroke-prone spontaneously hypertensive rats JO - Clin Exp Pharmacol Physiol VL - 26 UR - https://doi.org/10.1046/j.1440-1681.1999.03055.x DO - 10.1046/j.1440-1681.1999.03055.x ID - Negishi1999 ER - TY - JOUR AU - Nabika, T. AU - Cui, Z. AU - Masuda, J. PY - 2004 DA - 2004// TI - The stroke-prone spontaneously hypertensive rat: how good is it as a model for cerebrovascular diseases? JO - Cell Mol Neurobiol VL - 24 UR - https://doi.org/10.1023/B:CEMN.0000036402.79129.2f DO - 10.1023/B:CEMN.0000036402.79129.2f ID - Nabika2004 ER - TY - JOUR AU - Mizutani, K. AU - Ikeda, K. AU - Kawai, Y. AU - Yamori, Y. PY - 2001 DA - 2001// TI - Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats JO - Clin Exp Pharmacol Physiol VL - 28 UR - https://doi.org/10.1046/j.1440-1681.2001.03415.x DO - 10.1046/j.1440-1681.2001.03415.x ID - Mizutani2001 ER - TY - JOUR AU - Enciu, A. M. AU - Gherghiceanu, M. AU - Popescu, B. O. PY - 2013 DA - 2013// TI - Triggers and effectors of oxidative stress at blood–brain barrier level: relevance for brain ageing and neurodegeneration JO - Oxid Med Cell Longev VL - 2013 UR - https://doi.org/10.1155/2013/297512 DO - 10.1155/2013/297512 ID - Enciu2013 ER - TY - JOUR AU - Fraser, P. A. PY - 2011 DA - 2011// TI - The role of free radical generation in increasing cerebrovascular permeability JO - Free Radic Biol Med VL - 51 UR - https://doi.org/10.1016/j.freeradbiomed.2011.06.003 DO - 10.1016/j.freeradbiomed.2011.06.003 ID - Fraser2011 ER - TY - JOUR AU - Mun-Bryce, S. AU - Rosenberg, G. A. PY - 1998 DA - 1998// TI - Matrix metalloproteinases in cerebrovascular disease JO - J Cereb Blood Flow Metab VL - 18 UR - https://doi.org/10.1097/00004647-199811000-00001 DO - 10.1097/00004647-199811000-00001 ID - Mun-Bryce1998 ER - TY - JOUR AU - Liebetrau, M. AU - Burggraf, D. AU - Wunderlich, N. AU - Jäger, G. AU - Linz, W. AU - Hamann, G. F. PY - 2005 DA - 2005// TI - ACE inhibition reduces activity of the plasminogen/plasmin and MMP systems in the brain of spontaneous hypertensive stroke-prone rats JO - Neurosci Lett VL - 376 UR - https://doi.org/10.1016/j.neulet.2004.11.061 DO - 10.1016/j.neulet.2004.11.061 ID - Liebetrau2005 ER - TY - JOUR AU - Batra, A. AU - Latour, L. L. AU - Ruetzler, C. A. AU - Hallenbeck, J. M. AU - Spatz, M. AU - Warach, S. PY - 2010 DA - 2010// TI - Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke JO - J Cereb Blood Flow Metab VL - 30 UR - https://doi.org/10.1038/jcbfm.2010.1 DO - 10.1038/jcbfm.2010.1 ID - Batra2010 ER - TY - JOUR AU - Rosenberg, G. A. AU - Cunningham, L. A. AU - Wallace, J. AU - Alexander, S. AU - Estrada, E. Y. AU - Grossetete, M. PY - 2001 DA - 2001// TI - Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures JO - Brain Res VL - 893 UR - https://doi.org/10.1016/S0006-8993(00)03294-7 DO - 10.1016/S0006-8993(00)03294-7 ID - Rosenberg2001 ER - TY - JOUR AU - Tejima, E. AU - Zhao, B. Q. AU - Tsuji, K. AU - Rosell, A. AU - Leyen, K. AU - Gonzalez, R. G. PY - 2007 DA - 2007// TI - Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage JO - J Cereb Blood Flow Metab VL - 27 UR - https://doi.org/10.1038/sj.jcbfm.9600354 DO - 10.1038/sj.jcbfm.9600354 ID - Tejima2007 ER - TY - JOUR AU - Jung, J. E. AU - Kim, G. S. AU - Chen, H. AU - Maier, C. M. AU - Narasimhan, P. AU - Song, Y. S. PY - 2010 DA - 2010// TI - Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection JO - Mol Neurobiol VL - 41 UR - https://doi.org/10.1007/s12035-010-8102-z DO - 10.1007/s12035-010-8102-z ID - Jung2010 ER - TY - STD TI - Lapchak PA, Wu Q. Vascular dysfunction in brain hemorrhage: translational pathways to developing new treatments from old targets. J Neurol Neurophysiol 2011;S1. doi:10.4172/2155-9562.S1-e001. ID - ref19 ER - TY - JOUR AU - Spallarossa, P. AU - Altieri, P. AU - Garibaldi, S. AU - Ghigliotti, G. AU - Barisione, C. AU - Manca, V. PY - 2006 DA - 2006// TI - Matrix metalloproteinase-2 and −9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase JO - Cardiovasc Res VL - 69 UR - https://doi.org/10.1016/j.cardiores.2005.08.009 DO - 10.1016/j.cardiores.2005.08.009 ID - Spallarossa2006 ER - TY - JOUR AU - Freeman, L. R. AU - Keller, J. N. PY - 1822 DA - 1822// TI - Oxidative stress and cerebral endothelial cells: regulation of the blood–brain-barrier and antioxidant based interventions JO - Biochim Biophys Acta VL - 2012 ID - Freeman1822 ER - TY - JOUR AU - Dixon, B. J. AU - Tang, J. AU - Zhang, J. H. PY - 2013 DA - 2013// TI - The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance JO - Med Gas Res VL - 3 UR - https://doi.org/10.1186/2045-9912-3-10 DO - 10.1186/2045-9912-3-10 ID - Dixon2013 ER - TY - JOUR AU - Ohsawa, I. AU - Ishikawa, M. AU - Takahashi, K. AU - Watanabe, M. AU - Nishimaki, K. AU - Yamagata, K. PY - 2007 DA - 2007// TI - Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals JO - Nat Med VL - 13 UR - https://doi.org/10.1038/nm1577 DO - 10.1038/nm1577 ID - Ohsawa2007 ER - TY - JOUR AU - Nagatani, K. AU - Nawashiro, H. AU - Takeuchi, S. AU - Tomura, S. AU - Otani, N. AU - Osada, H. PY - 2013 DA - 2013// TI - Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies JO - Med Gas Res VL - 3 UR - https://doi.org/10.1186/2045-9912-3-13 DO - 10.1186/2045-9912-3-13 ID - Nagatani2013 ER - TY - JOUR AU - Nagatani, K. AU - Wada, K. AU - Takeuchi, S. AU - Kobayashi, H. AU - Uozumi, Y. AU - Otani, N. PY - 2012 DA - 2012// TI - Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia JO - Shock VL - 37 UR - https://doi.org/10.1097/SHK.0b013e31824ed57c DO - 10.1097/SHK.0b013e31824ed57c ID - Nagatani2012 ER - TY - JOUR AU - Ishibashi, T. AU - Sato, B. AU - Rikitake, M. AU - Seo, T. AU - Kurokawa, R. AU - Hara, Y. PY - 2012 DA - 2012// TI - Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study JO - Med Gas Res VL - 2 UR - https://doi.org/10.1186/2045-9912-2-27 DO - 10.1186/2045-9912-2-27 ID - Ishibashi2012 ER - TY - JOUR AU - Sun, Q. AU - Kawamura, T. AU - Masutani, K. AU - Peng, X. AU - Sun, Q. AU - Stolz, D. B. PY - 2012 DA - 2012// TI - Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats JO - Cardiovasc Res VL - 94 UR - https://doi.org/10.1093/cvr/cvs024 DO - 10.1093/cvr/cvs024 ID - Sun2012 ER - TY - JOUR AU - Chen, C. H. AU - Manaenko, A. AU - Zhan, Y. AU - Liu, W. W. AU - Ostrowki, R. P. AU - Tang, J. PY - 2010 DA - 2010// TI - Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model JO - Neuroscience VL - 169 UR - https://doi.org/10.1016/j.neuroscience.2010.04.043 DO - 10.1016/j.neuroscience.2010.04.043 ID - Chen2010 ER - TY - JOUR AU - Seo, T. AU - Kurokawa, R. AU - Sato, B. PY - 2012 DA - 2012// TI - A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum JO - Med Gas Res VL - 2 UR - https://doi.org/10.1186/2045-9912-2-1 DO - 10.1186/2045-9912-2-1 ID - Seo2012 ER - TY - JOUR AU - Cai, J. AU - Kang, Z. AU - Liu, K. AU - Liu, W. AU - Li, R. AU - Zhang, J. H. PY - 2009 DA - 2009// TI - Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model JO - Brain Res VL - 1256 UR - https://doi.org/10.1016/j.brainres.2008.11.048 DO - 10.1016/j.brainres.2008.11.048 ID - Cai2009 ER - TY - JOUR AU - Ge, Y. AU - Wu, F. AU - Sun, X. AU - Xiang, Z. AU - Yang, L. AU - Huang, S. PY - 2014 DA - 2014// TI - Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0097436 DO - 10.1371/journal.pone.0097436 ID - Ge2014 ER - TY - JOUR AU - Nagaoka, A. AU - Kakihana, M. AU - Fujiwara, K. PY - 1989 DA - 1989// TI - Effects of idebenone on neurological deficits following cerebrovascular lesions in stroke-prone spontaneously hypertensive rats JO - Arch Gerontol Geriatr VL - 8 UR - https://doi.org/10.1016/0167-4943(89)90003-4 DO - 10.1016/0167-4943(89)90003-4 ID - Nagaoka1989 ER - TY - JOUR AU - Nittby, H. AU - Brun, A. AU - Eberhardt, J. AU - Malmgren, L. AU - Persson, B. R. AU - Salford, L. G. PY - 2009 DA - 2009// TI - Increased blood–brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone JO - Pathophysiology VL - 16 UR - https://doi.org/10.1016/j.pathophys.2009.01.001 DO - 10.1016/j.pathophys.2009.01.001 ID - Nittby2009 ER - TY - JOUR AU - Gasche, Y. AU - Fujimura, M. AU - Morita-Fujimura, Y. AU - Copin, J. C. AU - Kawase, M. AU - Massengale, J. PY - 1999 DA - 1999// TI - Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood–brain barrier dysfunction JO - J Cereb Blood Flow Metab VL - 19 UR - https://doi.org/10.1097/00004647-199909000-00010 DO - 10.1097/00004647-199909000-00010 ID - Gasche1999 ER - TY - JOUR AU - Rosenberg, G. A. AU - Navratil, M. AU - Barone, F. AU - Feuerstein, G. PY - 1996 DA - 1996// TI - Proteolytic cascade enzymes increase in focal cerebral ischemia in rat JO - J Cereb Blood Flow Metab VL - 16 UR - https://doi.org/10.1097/00004647-199605000-00002 DO - 10.1097/00004647-199605000-00002 ID - Rosenberg1996 ER - TY - JOUR AU - Spindler, K. R. AU - Hsu, T. H. PY - 2012 DA - 2012// TI - Viral disruption of the blood–brain barrier JO - Trends Microbiol VL - 20 UR - https://doi.org/10.1016/j.tim.2012.03.009 DO - 10.1016/j.tim.2012.03.009 ID - Spindler2012 ER - TY - JOUR AU - Fonseca, A. C. AU - Matias, D. AU - Garcia, C. AU - Amaral, R. AU - Geraldo, L. H. AU - Freitas, C. PY - 2014 DA - 2014// TI - The impact of microglial activation on blood–brain barrier in brain diseases JO - Front Cell Neurosci VL - 8 UR - https://doi.org/10.3389/fncel.2014.00362 DO - 10.3389/fncel.2014.00362 ID - Fonseca2014 ER - TY - JOUR AU - Sumi, N. AU - Nishioku, T. AU - Takata, F. AU - Matsumoto, J. AU - Watanabe, T. AU - Shuto, H. PY - 2010 DA - 2010// TI - Lipopolysaccharide-activated microglia induce dysfunction of the blood–brain barrier in rat microvascular endothelial cells co-cultured with microglia JO - Cell Mol Neurobiol VL - 30 UR - https://doi.org/10.1007/s10571-009-9446-7 DO - 10.1007/s10571-009-9446-7 ID - Sumi2010 ER - TY - JOUR AU - Truettner, J. S. AU - Alonso, O. F. AU - Dalton Dietrich, W. PY - 2005 DA - 2005// TI - Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats JO - J Cereb Blood Flow Metab VL - 25 UR - https://doi.org/10.1038/sj.jcbfm.9600150 DO - 10.1038/sj.jcbfm.9600150 ID - Truettner2005 ER - TY - JOUR AU - Lin, J. X. AU - Tomimoto, H. AU - Akiguchi, I. AU - Wakita, H. AU - Shibasaki, H. AU - Horie, R. PY - 2001 DA - 2001// TI - White matter lesions and alteration of vascular cell composition in the brain of spontaneously hypertensive rats JO - Neuroreport VL - 12 UR - https://doi.org/10.1097/00001756-200107030-00015 DO - 10.1097/00001756-200107030-00015 ID - Lin2001 ER - TY - JOUR AU - Marks, L. AU - Carswell, H. V. AU - Peters, E. E. AU - Graham, D. I. AU - Patterson, J. AU - Dominiczak, A. F. PY - 2001 DA - 2001// TI - Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat JO - Hypertension VL - 38 UR - https://doi.org/10.1161/01.HYP.38.1.116 DO - 10.1161/01.HYP.38.1.116 ID - Marks2001 ER - TY - JOUR AU - Fujita, Y. AU - Lin, J. X. AU - Takahashi, R. AU - Tomimoto, H. PY - 2008 DA - 2008// TI - Cilostazol alleviates cerebral small-vessel pathology and white-matter lesions in stroke-prone spontaneously hypertensive rats JO - Brain Res VL - 1203 UR - https://doi.org/10.1016/j.brainres.2008.01.103 DO - 10.1016/j.brainres.2008.01.103 ID - Fujita2008 ER - TY - JOUR AU - Liu, G. D. AU - Zhang, H. AU - Wang, L. AU - Han, Q. AU - Zhou, S. F. AU - Liu, P. PY - 2013 DA - 2013// TI - Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells JO - Int J Ophthalmol VL - 6 ID - Liu2013 ER -