TY - JOUR AU - Takeuchi, Satoru AU - Nagatani, Kimihiro AU - Otani, Naoki AU - Nawashiro, Hiroshi AU - Sugawara, Takashi AU - Wada, Kojiro AU - Mori, Kentaro PY - 2015 DA - 2015/04/20 TI - Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats JO - BMC Neuroscience SP - 22 VL - 16 IS - 1 AB - Enhanced oxidative stress occurs in spontaneously hypertensive stroke-prone rats (SHRSP), and is important in blood–brain barrier (BBB) disruption. Hydrogen can exert potent protective cellular effects via reduction in oxidative stress in various diseases. The present study investigated whether long-term hydrogen treatment can improve neurological function outcome in the SHRSP model, and the effects of hydrogen on BBB function, especially the oxidative stress and the activity of matrix metalloproteinases (MMPs) in this model. Fifty-six animals were randomly assigned to 2 groups and treated as follows: SHRSP treated with hydrogen-rich water (HRW) (HRW group, n = 28); and SHRSP treated with regular water (control group, n = 28). The effect of HRW on overall survival and neurological function, and the effects of HRW on reactive oxygen species, BBB function, and MMP activities were examined. SN - 1471-2202 UR - https://doi.org/10.1186/s12868-015-0165-3 DO - 10.1186/s12868-015-0165-3 ID - Takeuchi2015 ER -