Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster

Table 1 Maximal current conductances (g _max ; mS/cm ² ) for the Full, 1089 Compartment model and the Simplified, Two Compartment model

Current	Soma	Dendrite(1089 compartment model)	Dendrite (two compartment model)
Resurgent Na⁺	156	0	0
P-type Ca²⁺	0.52	1.6	9.856
T-type Ca²⁺	0	0.6	3.696
E-type Ca²⁺	0	3.2	19.712
A-type K⁺	0	32	197.12
D-type K⁺	0	36	221.76
M-type K⁺	0	0.004	0.0246
Delayed rectifier K⁺	0	0.24	1.478
Bk K⁺	72.8	60	369.6
SK K⁺	10	0	0
K2 K⁺	0	0.16	0.986
Kv1.2 K⁺	0	1	6.16
Highly TEA sensitive K⁺	41.6	0	0
Moderately TEA sensitive K⁺	20.8	0	0
TEA insenstitive K⁺	41.6	0	0
hyperpolarization activated cation, I_h	1.04	0.29	1.786
Leak	0.1	0.000079	0.000487

These models have the same g_max values at the soma but not in the dendrite. In the dendrite of the Two Compartment model, g_max values are different because they are multiplied by the dendritic correction factor, C _d (=6.16; refer Methods).

ISSN: 1471-2202