Figure 5

Simulation of alcohol action upon the 1089 compartment Purkinje neuron model. A, Membrane potential at the soma. The red arrow, labelled “Alcohol”, symbolises the introduction of alcohol to the model Purkinje cell. A progressing alcohol block of Na⁺/K⁺ pumps is symbolised by the negatively orientated red arrow, labelled “Sodium-Potassium Pump Activity”. The model progresses through activity states: Quiescent, Bimodal, Tonic and Depolarisation Block. Only the onset of a depolarisation block can be observed because the simulation terminates at 90 seconds (because of issues with the computational expense of the model; refer Results). B, Membrane potential at the dendrite (spiny compartment 1001).