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Figure 1 | BMC Neuroscience

Figure 1

From: Increase in the titer of lentiviral vectors expressing potassium channels by current blockade during viral vector production

Figure 1

Schematic illustration of lentiviral vectors. Structures of the lentiviral self-inactivating expression plasmids Lv-Kir2.1, Lv-Kir-DN, Lv-GFP, Lv-synapsinP-Kir2.1, Lv-ΔCMV-synapsinP-Kir2.1, Lv-ΔCMV-LTR-RRE-cPPT-synapsinP-Kir2.1, Lv-Kv1.4, Lv-TREK, and Lv-HERG. The upstream CMV promoter was used to transcribe the viral genomic RNA. CMV, cytomegalovirus promoter; LTR, long terminal repeat; ψ, RNA packaging signal; RRE, Rev-responsive element; cPPT, central polypurine tract; β-actin, promoter of chick β-actin gene; synapsin, human synapsin I promoter; GFP, green fluorescent protein gene; NLS, nuclear localization signal; WPRE, posttranscriptional regulatory element of woodchuck hepatitis virus; , deletion in the U3 region of the 3′-LTR.

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