Figure 1

dapk-1 is an important mediator of nematode excitotoxicity. A) Dynamics of neurodegeneration in nematode excitotoxicity during development (using the glt-3;nuIs5 excitotoxicity model). dapk-1 ko mutation suppresses neurodegeneration in all developmental stages, but does not bring it down to background levels. B) Overexpression of wt dapk-1 from a heat-shock promoter enhances neurodegeneration compared to matched controls. In all bar graphs, error bars represent SE. Statistical significance is calculated using z score. *p < 0.05; ***p < 0.01.