Figure 4

Correlation in Mediator complex. Triangular correlation matrices of mouse Mediator complex (according to CORUM database) in AD11 and control mice at 1, 3, 6, and 15 months of age. The gene symbols are along the matrix. Correlation values go from −1.0 (red) to +1.0 (green). The blue arrows indicate that changes in the correlation network are statistically significant only at 1 month in Table 2. At 3, 6, 15 months of age the correlation matrices are similar, but at 1 month Med6 and Thrap3 (also known as Trap150) are heavily anti-correlated only in AD11 mice. These two genes are highlighted in red.