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Table 1 Pharmacological profiles of GABA A ligands at α4β1 and α4β1δ receptors

From: Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes

 

EC 50 (μM) (pEC 50± SEM)

IC 50 (μM) (pIC 50± SEM)

n H (± SEM)

N

GABA

 

α4β1δ

0.89 (6.05 ± 0.05)

 

1.1 ± 0.11

6

α4β1

2.7 (5.56 ± 0.05)

 

0.87 ± 0.079

5

Zn 2+

α4β1δ

 

3.3 (5.48 ± 0.03)

−0.75 ± 0.041

6

α4β1a

 

IC 50A

 

6

  

0.00013 (9.87 ± 0.22)

ND

 
  

IC 50B

  
  

0.056 (7.25 ± 0.13)

-1.1 ± 0.13

 

Cu 2+

α4β1δ

 

0.82 (6.09 ± 0.04)

−1.2 ± 0.13

12

SCS

α4β1δ

 

0.0042 (8.37 ± 0.25)

 

4

  1. Potencies for GABA, Zn2+, Cu2+ and SCS at α4β1 and α4β1δ receptors are listed. For Zn2+ and Cu2+, inhibition was measured at the GABA EC75. For SCS, inhibition was measured at the GABA EC20. ND, not determined. a Data fit a two-site model (IC50A & IC50B) better than a one-site model as determined by an F-test (p < 0.0001).