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Table 1 Pharmacological profiles of GABA A ligands at α4β1 and α4β1δ receptors

From: Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes

  EC 50 (μM) (pEC 50± SEM) IC 50 (μM) (pIC 50± SEM) n H (± SEM) N
GABA  
α4β1δ 0.89 (6.05 ± 0.05)   1.1 ± 0.11 6
α4β1 2.7 (5.56 ± 0.05)   0.87 ± 0.079 5
Zn 2+
α4β1δ   3.3 (5.48 ± 0.03) −0.75 ± 0.041 6
α4β1a   IC 50A   6
   0.00013 (9.87 ± 0.22) ND  
   IC 50B   
   0.056 (7.25 ± 0.13) -1.1 ± 0.13  
Cu 2+
α4β1δ   0.82 (6.09 ± 0.04) −1.2 ± 0.13 12
SCS
α4β1δ   0.0042 (8.37 ± 0.25)   4
  1. Potencies for GABA, Zn2+, Cu2+ and SCS at α4β1 and α4β1δ receptors are listed. For Zn2+ and Cu2+, inhibition was measured at the GABA EC75. For SCS, inhibition was measured at the GABA EC20. ND, not determined. a Data fit a two-site model (IC50A & IC50B) better than a one-site model as determined by an F-test (p < 0.0001).