Figure 2From: Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes Pharmacological modulation of GABA responses at α4β1δ receptors by various inhibitors and the neurosteroid, THDOC. A, Representative membrane currents showing inhibition of GABA (EC75) by 1 μM Zn2+ at α4β1 (upper) and α4β1δ (lower) receptors. B, Zn2+ concentration-inhibition relationships for α4β1 (n = 6) and α4β1δ (n = 6) receptors. C, Representative currents showing the degree of desensitization when activated by EC75 GABA in the absence (upper) and presence (lower) of 1 μM Cu2+. D, Cu2+ concentration-inhibition relationship for GABA EC75 desensitized responses at α4β1δ receptors by increasing concentrations of Cu2+ (n = 12). E, SCS concentration-inhibition relationship for GABA EC20 peak responses at α4β1δ receptors by increasing concentrations of SCS (n = 4). F, Response of α4β1δ receptors to increasing concentrations of THDOC co-applied with an EC7 GABA concentration. The responses were normalised to a preceding application of GABA EC7 in the absence of THDOC (n = 9). All data shown are means ± SEMs.Back to article page