Duration of tonic hindlimb extension induced by maximal electroshock after the administration of mefloquine. The duration of tonic hindlimb extension (THLE) was significantly reduced after the administration of different doses of mefloquine (MFQ). Values are expressed in seconds as mean ± SEM. The level of significance (*p < 0.05) was determined by nonparametric Kruskal-Wallis analysis followed by Dunnet test. Vehicle (n = 6), MFQ 20 mg/kg (n = 6), MFQ 40 mg/kg (n = 6), MFQ 80 mg/kg (n = 6).