Figure 3From: Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats Mefloquine significantly modifies the total spectral power of the EEG and some parameters of the epileptiform activity induced by pentylenetetrazole. Mefloquine (MFQ) (40 mg/kg) significantly decreased the total spectral power and modified the epileptiform activity in rats administered with pentylenetetrazole (PTZ). A) Total spectral power acquired in the frequency ranges of 0–32 Hz; error bars represent SEM. B) Representative EEG traces obtained in 10-seconds epochs during basal recording and post-administration of vehicle or MFQ and PTZ. C) Duration, D) Amplitude and E) Frequency of the epileptiform activity induced by PTZ. MFQ significantly modified these parameters. *p < 0.05 statistically significant compared with the control group (vehicle + PTZ). #p < 0.05 statistically significant compared with the basal recording. The total spectral power was analyzed using a Nonparametric Kruskal-Wallis analysis followed by Student Newman Keuls test. The duration, amplitude, and frequency were compared with a Mann–Whitney rank sum test. Vehicle + PTZ (n = 8), MFQ 40 mg/kg + PTZ (n = 8).Back to article page