Influence of mefloquine on the latency to the first myoclonic jerk induced by pentylenetetrazole. The latency to the first myoclonic jerk was significantly increased after the administration of mefloquine (MFQ) 40 mg/kg. Values are expressed in minutes as mean ± SEM. The level of significance (*p < 0.05) was determined by nonparametric Kruskal-Wallis analysis followed by Dunnet test. Vehicle + PTZ (n = 8), MFQ 20 mg/kg + PTZ (n = 8), MFQ 40 mg/kg + PTZ (n = 8), MFQ 80 mg/kg + PTZ (n = 8).