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Table 2 Correlations between TrkB mRNA expression and neurogenic markers in the hippocampus

From: The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: relationship with cell proliferation

All monkeys

r-value

p-value

Ki67 vs TrkB-TK+

0.68

0.016*

Ki67 vs TrkB-TK-

−0.19

0.56

DCX vs TrkB-TK+

0.40

0.20

DCX vs TrkB-TK-

−0.035

0.91

BrdU vs TrkB-TK+

0.42

0.20

BrdU vs TrkB-TK-

0.18

0.60

All rat groups

r-value

p-value

Ki67 vs TrkB-TK+

0.80

<0.00001***

Ki67 vs TrkB-T1

0.19

0.12

Ki67 vs TrkB-T2

0.021

0.86

DCX vs TrkB-TK+

0.88

<0.00001***

DCX vs TrkB-T1

0.064

0.60

DCX vs TrkB-T2

0.077

0.53

TUC4 vs TrkB-TK+

0.88

<0.00001***

TUC4 vs TrkB-T1

0.23

0.058

TUC4 vs TrkB-T2

0.16

0.21

  1. In all 12 rhesus macaques, TrkB-TK+ mRNA expression (in situ hybridisation) was positively correlated with the density of Ki67 labelled cells in the dentate gyrus. In all Sprague Dawley rat treatment groups, TrkB-TK+ mRNA expression was positively correlated with Ki67 mRNA expression, DCX mRNA expression and TUC4 mRNA expression. *p < 0.05, ***p < 0.001, bold type=p≤0.05.
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BMC Neuroscience

ISSN: 1471-2202

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