TY - JOUR AU - Allen, Katherine M. AU - Purves-Tyson, Tertia D. AU - Fung, Samantha J. AU - Shannon Weickert, Cynthia PY - 2015 DA - 2015/02/18 TI - The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: relationship with cell proliferation JO - BMC Neuroscience SP - 4 VL - 16 IS - 1 AB - Testosterone attenuates postnatal hippocampal neurogenesis in adolescent male rhesus macaques through altering neuronal survival. While brain-derived neurotropic factor (BDNF)/ tyrosine kinase receptor B (TrkB) are critical in regulating neuronal survival, it is not known if the molecular mechanism underlying testosterone’s action on postnatal neurogenesis involves changes in BDNF/TrkB levels. First, (1) we sought to localize the site of synthesis of the full length and truncated TrkB receptor in the neurogenic regions of the adolescent rhesus macaque hippocampus. Next, (2) we asked if gonadectomy or sex hormone replacement altered hippocampal BDNF and TrkB expression level in mammalian hippocampus (rhesus macaque and Sprague Dawley rat), and (3) if the relationship between BDNF/TrkB expression was altered depending on the sex steroid environment. SN - 1471-2202 UR - https://doi.org/10.1186/s12868-015-0142-x DO - 10.1186/s12868-015-0142-x ID - Allen2015 ER -