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Figure 3 | BMC Neuroscience

Figure 3

From: Noise alters guinea pig’s blood-labyrinth barrier ultrastructure and permeability along with a decrease of cochlear Claudin-5 and Occludin

Figure 3

The expressions of Claudin-5 (A,B,C) and Occludin (A’,B’,C’) in cochleae after NE 4 h or NE 2d were analyzed with immunohistochemistry. A) Normal expression of Claudin-5 in cochlea. A') Normal expression of Occludin in cochlea. B) The decreased expression of Claudin-5 in cochlea after NE 4h. B') The decreased expression of Occludin in cochlea after NE 4h. C) The decreased expression of Claudin-5 in cochlea after NE 2d. C') The decreased expression of Occludin in cochlea after NE 2d. D) Normal structure of cochlea stained by HE. E) The expression of Claudin-5 and Occludin in cochleae were analyzed by optical density. The regions used for analysis was shown in D. The relative expression levels for Claudin-5 and Occludin were shown in E. Scale bar = 100 μm. *P < 0.05, **P < 0.05.

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