No effects of NGEN on I
in NSC-34 cells. In these experiments, cells were bathed in a high-K+, Ca2+-free solution. Each cell was held at -10 mV and various voltage pulses ranging from -110 to 0 mV with 10-mV increments were applied as shown in the uppermost part of (A). (A) Superimposed I K(erg) obtained in the absence (upper) and presence (lower) of 10 μM NGEN. (B) Averaged I-V relationship of peak I K(erg) obtained in control (■) and during exposure to 10 μM NGEN (□) (mean ± SEM; n = 8-13 for each point).