Figure 10
Burst firing of APs (upper parts) and the corresponding changes of I K(M) and I K(Ca) (lower parts) in modeled hippocampal neuron. The detailed formulations were described under Methods. The firing was generated with the values of gM and gKCa was set at 0.02 and 0.05 mS/cm2(Aa), 0.04 and 0.05 mS/cm2(Ba) and 0.04 and 0.1 mS/cm2(Ca), respectively. Ab, Bb, and Cb indicate the corresponding changes in I K(M) (blue solid lines) and I K(Ca) (red dashed lines), respectively. In (C), the values of gM and gKCa were arbitrarily elevated by two-fold to mimic the stimulatory effects of NGEN (10 μM). Note that in this simulation, the amplitudes of I K(M) are smaller than those of I K(Ca).