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Table 2 T-maze data for animals following MCAO

From: Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice

  

Sham

Progesterone

Vehicle/Non-treated

Day

Outcome

Adult C57 Bl/6

Adult C57 Bl/6

Hypertensive

Adult C57 Bl/6

Hypertensive

5

% Alternation

  

16.67 ± 7.45

 

33.33 ± 16.67

 

% Contralateral/Ipsilateral Ratio

  

34.29 ± 12.45

 

61.90 ± 20.76

 

Time Taken (mins)

  

3.31 ± 0.27

 

3.81 ± 0.27

6

% Alternation

  

16.67 ± 10.54

 

11.11 ± 11.11

 

% Contralateral/Ipsilateral Ratio

  

25.71 ± 17.14*

 

95.24 ± 4.76

 

Time Taken (mins)

  

3.51 ± 0.27*

 

5.52 ± 0.80

7

% Alternation

58.34 ± 4.81

38.89 ± 12.67

26.67 ± 16.33

50.00 ± 9.62

33.33 ± 19.25

 

% Contralateral/Ipsilateral Ratio

57.14 ± 5.83

54.62 ± 14.03

17.14 ± 10.50

57.14 ± 14.29

71.43 ± 14.29

 

Time Taken (mins)

7.78 ± 0.94

6.27 ± 0.91

3.84 ± 0.35*

5.59 ± 0.21

5.59 ± 0.76

  1. There was no significant difference between groups in terms of % alternation rate, contralateral/ipsilateral alternation ratio (%), or time taken to complete trials in adult mice (progesterone n = 6, vehicle n = 3, sham n = 4). In hypertensive BPH/2 mice, there was no difference found between progesterone and non-treated groups in t-maze alternation %, but progesterone treated animals had a significantly greater contralateral goal arm preference than non-treated groups (P = 0.0006). Data expressed as mean ± SEM (progesterone n = 5, vehicle n = 4).