IL-1β expression was suppressed following treatment of LPS-activated microglia with drugs E, S and E + S in vitro . Confocal images show an upregulation of IL-1β (E) in LPS-activated BV-2 microglia (D) in comparison to control (A-C). IL-1β was hardly detected (H, K, N) in activated microglia treated with drugs E, S and especially so with E + S (G, J, M). DAPI - blue. Scale bars in A-O: 50 μm.