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Figure 8 | BMC Neuroscience

Figure 8

From: Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia

Figure 8

TNF-α expression was suppressed following treatment of LPS-activated microglia with drugs E, S and E + S in vitro . Confocal images show an upregulation of TNFα (E) in LPS-activated BV-2 microglia (D) in comparison to control (A-C). Addition of drugs E and S led to decrease in the expression of TNF-α (H, K) in LPS-activated BV-2 microglia (G, J). TNF-α was hardly detected in activated microglia when treated with a combination of drugs E and S (N). Following treatment with drugs E and S, activated microglia emitted thin cytoplasmic processes (M) reminiscent of the ramified microglia in vivo. DAPI - blue. Scale bars in A-O: 50 μm

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BMC Neuroscience

ISSN: 1471-2202

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