Skip to main content
Figure 6 | BMC Neuroscience

Figure 6

From: Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia

Figure 6

Treatment of MCAO rats with drugs E, SH and E + SH resulted in the reduction of IL-1β expression in activated microglia. Confocal images showing the expression of IL-1β (red) in lectin+ microglia (green) in the penumbral zones of MCAO rat brain (D-F) and following treatment with E (G-I), SH (J-L) and E + SH (M-O) (n = 5 for each group). A noticeable increase in IL-1β expression (E) can be observed in the activated microglia (D) in MCAO rat brain. IL-1β expression (H, K), however, was depressed in activated microglia (G, J) 3 days following treatment of MCAO rats with drugs E and SH. Also, IL-1β expression (N) was almost totally abolished in activated microglia (M) when MCAO rats were treated with a combination of the two drugs. DAPI - blue. Scale bars in A-O: 50 μm

Back to article page