NO expression was reduced in LPS-activated microglial cells following treatment with E, S and E + S. Intracellular NO in LPS-activated BV-2 microglial cells following treatment with E, S and E + S was measured. Confocal images showing the expression of NO (red) in LPS-induced microglia (transmitted) (D-F) and following treatment with E (G-I), S (J-L) and E + S (M-O). Increase in NO expression (D) can be observed in LPS-activated BV-2 microglia (E) in comparison to control (A-C). Addition of drug E led to decrease in the expression of NO (G) in LPS-activated BV-2 microglia (H). NO expression was significantly suppressed in activated microglia treated with drug S (J) and a combination of drugs E and S (M). Scale bars in A-O: 20 μm.