iNOS expression was drastically suppressed following treatment of LPS-activated microglia with drugs E, S and E + S in vitro . Confocal images show an upregulation of iNOS (E) in LPS-activated BV-2 microglia (D) in comparison to control (A-C). Addition of drug E resulted in decrease in iNOS expression (H) in LPS-activated BV-2 microglia (G). iNOS expression was obliterated in activated microglia treated with drug S (K) notably with a combination of drugs E and S (N). DAPI - blue. Scale bars in A-O: 50 μm.