Effects of flupenthixol on locomotor activity. Mean cumulative distance (± SEM) moved in an open field in animals (n = 12) under saline (1 ml/kg, i.p.) vs. flupenthixol (0.25 mg/kg, i.p.) administered 60 min prior CPP testing. An ANOVA revealed a trend for an effect of treatment (F(1,11) =4.69; p =0.053) and a significant treatment × time interaction (F(8,88) =2.06; p < 0.05).