Figure 2
From: Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine
Time-dependent fluctuation of CREB, αCaM kinase II, MAPK/Erk1/2 in HPC nuclei. Modulation by chronic agomelatine. Expression levels of CREB (A), αCaM kinase II (C), MAPK/Erk1 (E) and MAPK/Erk2 (G) and phosphorylation levels of CREB at Ser133(B), αCaM kinase II at Thr286(D), MAPK/Erk1 at Thr202/204(F) and MAPK/Erk2 at Thr202/204(H) in nuclear fraction of HPC from rats chronically treated with vehicle (VEH, black bar) or agomelatine (AGO, white bar) and sacrificed 1 or 16 h after the last injection. Data expressed as above. Statistics as above. **p < 0.01 VEH 16 h after last injection vs. VEH 1 h after last injection; §§§p < 0.001 AGO 16 h after last injection vs. AGO 1 h after last injection (n =8 rats/group).