Figure 5

Voxel-based correlation analyses between the phase values and clinical variables in the patients with mTLE. Warm color denotes positive correlation, and cold color denotes negative correlation (p < 0.05, FDR correction). A: Correlation between phase values and epilepsy duration. The cortical and subcortical structures both showed negative correlation, denotes that the iron concentrations in these brain regions are positive correlated with epilepsy duration. B: Correlation between phase values and ages at seizures onset. Negative correlation was found between the subcortical structures including the GPe, PUT, SN and RN. In the results of A and B, the nucleus of GPi showed dissociated presence with the other subcortical nuclei. C: Correlation between phase values and seizures frequency. No meaningful region was found to have correlation. The results are shown by overlying on MNI 305 template image. Abbreviations: L: left; R: right; PUT: putamen; GPi: internal globus pallidus; GPe: external globus pallidus; SN: substantia nigra; RN: red nucleus.