TY - JOUR AU - Bartzokis, G. AU - Mintz, J. AU - Sultzer, D. AU - Marx, P. AU - Herzberg, J. S. AU - Phelan, C. K. AU - Marder, S. R. PY - 1994 DA - 1994// TI - In vivoMR evaluation of age-related increases in brain iron JO - AJNR Am J Neuroradiol VL - 15 ID - Bartzokis1994 ER - TY - JOUR AU - Bartzokis, G. AU - Beckson, M. AU - Hance, D. B. AU - Marx, P. AU - Foster, J. A. AU - Marder, S. R. PY - 1997 DA - 1997// TI - MR evaluation of age-related increase of brain iron in young adult and older normal males JO - Magn Reson Imaging VL - 15 UR - https://doi.org/10.1016/S0730-725X(96)00234-2 DO - 10.1016/S0730-725X(96)00234-2 ID - Bartzokis1997 ER - TY - JOUR AU - Zecca, L. AU - Youdim, M. B. AU - Riederer, P. AU - Connor, J. R. AU - Crichton, R. R. PY - 2004 DA - 2004// TI - Iron, brain ageing and neurodegenerative disorders JO - Nat Rev Neurosci VL - 5 UR - https://doi.org/10.1038/nrn1537 DO - 10.1038/nrn1537 ID - Zecca2004 ER - TY - JOUR AU - Halliwell, B. PY - 2001 DA - 2001// TI - Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment JO - Drugs Aging VL - 18 UR - https://doi.org/10.2165/00002512-200118090-00004 DO - 10.2165/00002512-200118090-00004 ID - Halliwell2001 ER - TY - JOUR AU - Sayre, L. M. AU - Smith, M. A. AU - Perry, G. PY - 2001 DA - 2001// TI - Chemistry and biochemistry of oxidative stress in neurodegenerative disease JO - Curr Med Chem VL - 8 UR - https://doi.org/10.2174/0929867013372922 DO - 10.2174/0929867013372922 ID - Sayre2001 ER - TY - JOUR AU - Lovell, M. A. AU - Robertson, J. D. AU - Teesdale, W. J. AU - Campbell, J. L. AU - Markesbery, W. R. PY - 1998 DA - 1998// TI - Copper, iron and zinc in Alzheimer's disease senile plaques JO - J Neurol Sci VL - 158 UR - https://doi.org/10.1016/S0022-510X(98)00092-6 DO - 10.1016/S0022-510X(98)00092-6 ID - Lovell1998 ER - TY - JOUR AU - Pinero, D. J. AU - Hu, J. AU - Connor, J. R. PY - 2000 DA - 2000// TI - Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains JO - Cell Mol Biol VL - 46 ID - Pinero2000 ER - TY - JOUR AU - Smith, M. A. AU - Hirai, K. AU - Hsiao, K. AU - Pappolla, M. A. AU - Harris, P. L. AU - Siedlak, S. L. AU - Tabaton, M. AU - Perry, G. PY - 1998 DA - 1998// TI - Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress JO - J Neurochem VL - 70 UR - https://doi.org/10.1046/j.1471-4159.1998.70052212.x DO - 10.1046/j.1471-4159.1998.70052212.x ID - Smith1998 ER - TY - JOUR AU - Moreira, P. I. AU - Siedlak, S. L. AU - Aliev, G. AU - Zhu, X. AU - Cash, A. D. AU - Smith, M. A. AU - Perry, G. PY - 2005 DA - 2005// TI - Oxidative stress mechanisms and potential therapeutics in Alzheimer disease JO - J Neural Transm VL - 112 UR - https://doi.org/10.1007/s00702-004-0242-8 DO - 10.1007/s00702-004-0242-8 ID - Moreira2005 ER - TY - JOUR AU - Castellani, R. J. AU - Honda, K. AU - Zhu, X. AU - Cash, A. D. AU - Nunomura, A. AU - Perry, G. AU - Smith, M. A. PY - 2004 DA - 2004// TI - Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease JO - Ageing Res Rev VL - 3 UR - https://doi.org/10.1016/j.arr.2004.01.002 DO - 10.1016/j.arr.2004.01.002 ID - Castellani2004 ER - TY - JOUR AU - Honda, K. AU - Casadesus, G. AU - Petersen, R. B. AU - Perry, G. AU - Smith, M. A. PY - 2004 DA - 2004// TI - Oxidative stress and redox-active iron in Alzheimer's disease JO - Ann N Y Acad Sci VL - 1012 UR - https://doi.org/10.1196/annals.1306.015 DO - 10.1196/annals.1306.015 ID - Honda2004 ER - TY - JOUR AU - Casadesus, G. AU - Smith, M. A. AU - Zhu, X. AU - Aliev, G. AU - Cash, A. D. AU - Honda, K. AU - Petersen, R. B. AU - Perry, G. PY - 2004 DA - 2004// TI - Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species JO - J Alzheimers Dis VL - 6 ID - Casadesus2004 ER - TY - JOUR AU - Takeda, A. AU - Smith, M. A. AU - Avila, J. AU - Nunomura, A. AU - Siedlak, S. L. AU - Zhu, X. AU - Perry, G. AU - Sayre, L. M. PY - 2000 DA - 2000// TI - In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification JO - J Neurochem VL - 75 UR - https://doi.org/10.1046/j.1471-4159.2000.0751234.x DO - 10.1046/j.1471-4159.2000.0751234.x ID - Takeda2000 ER - TY - JOUR AU - Shimohama, S. AU - Tanino, H. AU - Kawakami, N. AU - Okamura, N. AU - Kodama, H. AU - Yamaguchi, T. AU - Hayakawa, T. AU - Nunomura, A. AU - Chiba, S. AU - Perry, G. PY - 2000 DA - 2000// TI - Activation of NADPH oxidase in Alzheimer's disease brains JO - Biochem Biophys Res Commun VL - 273 UR - https://doi.org/10.1006/bbrc.2000.2897 DO - 10.1006/bbrc.2000.2897 ID - Shimohama2000 ER - TY - JOUR AU - Schipper, H. M. PY - 2000 DA - 2000// TI - Heme oxygenase-1: role in brain aging and neurodegeneration JO - Exp Gerontol VL - 35 UR - https://doi.org/10.1016/S0531-5565(00)00148-0 DO - 10.1016/S0531-5565(00)00148-0 ID - Schipper2000 ER - TY - JOUR AU - Honda, K. AU - Smith, M. A. AU - Zhu, X. AU - Baus, D. AU - Merrick, W. C. AU - Tartakoff, A. M. AU - Hattier, T. AU - Harris, P. L. AU - Siedlak, S. L. AU - Fujioka, H. PY - 2005 DA - 2005// TI - Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M500526200 DO - 10.1074/jbc.M500526200 ID - Honda2005 ER - TY - JOUR AU - Connor, J. R. AU - Menzies, S. L. AU - St Martin, S. M. AU - Mufson, E. J. PY - 1992 DA - 1992// TI - A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains JO - J Neurosci Res VL - 31 UR - https://doi.org/10.1002/jnr.490310111 DO - 10.1002/jnr.490310111 ID - Connor1992 ER - TY - JOUR AU - Yamada, T. AU - Tsujioka, Y. AU - Taguchi, J. AU - Takahashi, M. AU - Tsuboi, Y. AU - Moroo, I. AU - Yang, J. AU - Jefferies, W. A. PY - 1999 DA - 1999// TI - Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease JO - Brain Res VL - 845 UR - https://doi.org/10.1016/S0006-8993(99)01767-9 DO - 10.1016/S0006-8993(99)01767-9 ID - Yamada1999 ER - TY - JOUR AU - Grundke-Iqbal, I. AU - Fleming, J. AU - Tung, Y. C. AU - Lassmann, H. AU - Iqbal, K. AU - Joshi, J. G. PY - 1990 DA - 1990// TI - Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia JO - Acta Neuropathol VL - 81 UR - https://doi.org/10.1007/BF00334497 DO - 10.1007/BF00334497 ID - Grundke-Iqbal1990 ER - TY - JOUR AU - Moalem, S. AU - Percy, M. E. AU - Andrews, D. F. AU - Kruck, T. P. AU - Wong, S. AU - Dalton, A. J. AU - Mehta, P. AU - Fedor, B. AU - Warren, A. C. PY - 2000 DA - 2000// TI - Are hereditary hemochromatosis mutations involved in Alzheimer disease? JO - Am J Med Genet VL - 93 UR - https://doi.org/3.0.CO;2-L DO - 3.0.CO;2-L ID - Moalem2000 ER - TY - JOUR AU - Berlin, D. AU - Chong, G. AU - Chertkow, H. AU - Bergman, H. AU - Phillips, N. A. AU - Schipper, H. M. PY - 2004 DA - 2004// TI - Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCI JO - Neurobiol Aging VL - 25 UR - https://doi.org/10.1016/j.neurobiolaging.2003.06.008 DO - 10.1016/j.neurobiolaging.2003.06.008 ID - Berlin2004 ER - TY - JOUR AU - Bush, A. I. PY - 2003 DA - 2003// TI - The metallobiology of Alzheimer's disease JO - Trends Neurosci VL - 26 UR - https://doi.org/10.1016/S0166-2236(03)00067-5 DO - 10.1016/S0166-2236(03)00067-5 ID - Bush2003 ER - TY - JOUR AU - House, E. AU - Collingwood, J. AU - Khan, A. AU - Korchazkina, O. AU - Berthon, G. AU - Exley, C. PY - 2004 DA - 2004// TI - Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease JO - J Alzheimers Dis VL - 6 ID - House2004 ER - TY - JOUR AU - Yamamoto, A. AU - Shin, R. W. AU - Hasegawa, K. AU - Naiki, H. AU - Sato, H. AU - Yoshimasu, F. AU - Kitamoto, T. PY - 2002 DA - 2002// TI - Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease JO - J Neurochem VL - 82 UR - https://doi.org/10.1046/j.1471-4159.2002.t01-1-01061.x DO - 10.1046/j.1471-4159.2002.t01-1-01061.x ID - Yamamoto2002 ER - TY - JOUR AU - Rogers, J. T. AU - Randall, J. D. AU - Cahill, C. M. AU - Eder, P. S. AU - Huang, X. AU - Gunshin, H. AU - Leiter, L. AU - McPhee, J. AU - Sarang, S. S. AU - Utsuki, T. PY - 2002 DA - 2002// TI - An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M207435200 DO - 10.1074/jbc.M207435200 ID - Rogers2002 ER - TY - JOUR AU - Rogers, J. T. AU - Leiter, L. M. AU - McPhee, J. AU - Cahill, C. M. AU - Zhan, S. S. AU - Potter, H. AU - Nilsson, L. N. PY - 1999 DA - 1999// TI - Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.10.6421 DO - 10.1074/jbc.274.10.6421 ID - Rogers1999 ER - TY - JOUR AU - Atwood, C. S. AU - Obrenovich, M. E. AU - Liu, T. AU - Chan, H. AU - Perry, G. AU - Smith, M. A. AU - Martins, R. N. PY - 2003 DA - 2003// TI - Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta JO - Brain Res Brain Res Rev VL - 43 UR - https://doi.org/10.1016/S0165-0173(03)00174-7 DO - 10.1016/S0165-0173(03)00174-7 ID - Atwood2003 ER - TY - JOUR AU - Nunomura, A. AU - Perry, G. AU - Aliev, G. AU - Hirai, K. AU - Takeda, A. AU - Balraj, E. K. AU - Jones, P. K. AU - Ghanbari, H. AU - Wataya, T. AU - Shimohama, S. PY - 2001 DA - 2001// TI - Oxidative damage is the earliest event in Alzheimer disease JO - J Neuropathol Exp Neurol VL - 60 ID - Nunomura2001 ER - TY - JOUR AU - Moechars, D. AU - Dewachter, I. AU - Lorent, K. AU - Reverse, D. AU - Baekelandt, V. AU - Naidu, A. AU - Tesseur, I. AU - Spittaels, K. AU - Haute, C. V. AU - Checler, F. PY - 1999 DA - 1999// TI - Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.10.6483 DO - 10.1074/jbc.274.10.6483 ID - Moechars1999 ER - TY - JOUR AU - Misonou, H. AU - Morishima-Kawashima, M. AU - Ihara, Y. PY - 2000 DA - 2000// TI - Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells JO - Biochemistry VL - 39 UR - https://doi.org/10.1021/bi000169p DO - 10.1021/bi000169p ID - Misonou2000 ER - TY - JOUR AU - Paola, D. AU - Domenicotti, C. AU - Nitti, M. AU - Vitali, A. AU - Borghi, R. AU - Cottalasso, D. AU - Zaccheo, D. AU - Odetti, P. AU - Strocchi, P. AU - Marinari, U. M. PY - 2000 DA - 2000// TI - Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells JO - Biochem Biophys Res Commun VL - 268 UR - https://doi.org/10.1006/bbrc.2000.2164 DO - 10.1006/bbrc.2000.2164 ID - Paola2000 ER - TY - JOUR AU - Zhang, L. AU - Zhao, B. AU - Yew, D. T. AU - Kusiak, J. W. AU - Roth, G. S. PY - 1997 DA - 1997// TI - Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells JO - Biochem Biophys Res Commun VL - 235 UR - https://doi.org/10.1006/bbrc.1997.6698 DO - 10.1006/bbrc.1997.6698 ID - Zhang1997 ER - TY - JOUR AU - Abe, K. AU - St George-Hyslop, P. H. AU - Tanzi, R. E. AU - Kogure, K. PY - 1991 DA - 1991// TI - Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells JO - Neurosci Lett VL - 125 UR - https://doi.org/10.1016/0304-3940(91)90019-P DO - 10.1016/0304-3940(91)90019-P ID - Abe1991 ER - TY - JOUR AU - Shi, J. AU - Xiang, Y. AU - Simpkins, J. W. PY - 1997 DA - 1997// TI - Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells JO - Brain Res VL - 772 UR - https://doi.org/10.1016/S0006-8993(97)00827-5 DO - 10.1016/S0006-8993(97)00827-5 ID - Shi1997 ER - TY - JOUR AU - Shi, J. AU - Perry, G. AU - Smith, M. A. AU - Friedland, R. P. PY - 2000 DA - 2000// TI - Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease JO - Neurobiol Aging VL - 21 UR - https://doi.org/10.1016/S0197-4580(00)00119-6 DO - 10.1016/S0197-4580(00)00119-6 ID - Shi2000 ER - TY - JOUR AU - Tamagno, E. AU - Bardini, P. AU - Obbili, A. AU - Vitali, A. AU - Borghi, R. AU - Zaccheo, D. AU - Pronzato, M. A. AU - Danni, O. AU - Smith, M. A. AU - Perry, G. PY - 2002 DA - 2002// TI - Oxidative stress increases expression and activity of BACE in NT2 neurons JO - Neurobiol Dis VL - 10 UR - https://doi.org/10.1006/nbdi.2002.0515 DO - 10.1006/nbdi.2002.0515 ID - Tamagno2002 ER - TY - JOUR AU - Tamagno, E. AU - Parola, M. AU - Bardini, P. AU - Piccini, A. AU - Borghi, R. AU - Guglielmotto, M. AU - Santoro, G. AU - Davit, A. AU - Danni, O. AU - Smith, M. A. PY - 2005 DA - 2005// TI - Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways JO - J Neurochem VL - 92 UR - https://doi.org/10.1111/j.1471-4159.2004.02895.x DO - 10.1111/j.1471-4159.2004.02895.x ID - Tamagno2005 ER - TY - JOUR AU - Rogers, J. T. AU - Lahiri, D. K. PY - 2004 DA - 2004// TI - Metal and inflammatory targets for Alzheimer's disease JO - Curr Drug Targets VL - 5 UR - https://doi.org/10.2174/1389450043345272 DO - 10.2174/1389450043345272 ID - Rogers2004 ER - TY - JOUR AU - Robinson, S. R. AU - Bishop, G. M. PY - 2002 DA - 2002// TI - Abeta as a bioflocculant: implication for the amyloid hypothesis of Alzheimer's disease JO - Neurobiol Aging VL - 23 UR - https://doi.org/10.1016/S0197-4580(01)00342-6 DO - 10.1016/S0197-4580(01)00342-6 ID - Robinson2002 ER - TY - JOUR AU - Zou, K. AU - Gong, J. S. AU - Yanagisawa, K. AU - Michikawa, M. PY - 2002 DA - 2002// TI - A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage JO - J Neurosci VL - 22 ID - Zou2002 ER - TY - JOUR AU - Bishop, G. M. AU - Robinson, S. R. PY - 2004 DA - 2004// TI - The amyloid paradox: amyloid-beta-metal complexes can be neurotoxic and neuroprotective JO - Brain Pathol VL - 14 UR - https://doi.org/10.1111/j.1750-3639.2004.tb00089.x DO - 10.1111/j.1750-3639.2004.tb00089.x ID - Bishop2004 ER - TY - JOUR AU - Nakamura, M. AU - Shishido, N. AU - Nunomura, A. AU - Smith, M. A. AU - Perry, G. AU - Hayashi, Y. AU - Nakayama, K. AU - Hayashi, T. PY - 2007 DA - 2007// TI - Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron JO - Biochemistry VL - 46 UR - https://doi.org/10.1021/bi701079z DO - 10.1021/bi701079z ID - Nakamura2007 ER - TY - JOUR AU - Crapper McLachlan, D. R. AU - Dalton, A. J. AU - Kruck, T. P. AU - Bell, M. Y. AU - Smith, W. L. AU - Kalow, W. AU - Andrews, D. F. PY - 1991 DA - 1991// TI - Intramuscular desferrioxamine in patients with Alzheimer's disease JO - Lancet VL - 337 UR - https://doi.org/10.1016/0140-6736(91)92978-B DO - 10.1016/0140-6736(91)92978-B ID - Crapper McLachlan1991 ER - TY - JOUR AU - Cherny, R. A. AU - Atwood, C. S. AU - Xilinas, M. E. AU - Gray, D. N. AU - Jones, W. D. AU - McLean, C. A. AU - Barnham, K. J. AU - Volitakis, I. AU - Fraser, F. W. AU - Kim, Y. PY - 2001 DA - 2001// TI - Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice JO - Neuron VL - 30 UR - https://doi.org/10.1016/S0896-6273(01)00317-8 DO - 10.1016/S0896-6273(01)00317-8 ID - Cherny2001 ER - TY - JOUR AU - Ritchie, C. W. AU - Bush, A. I. AU - Mackinnon, A. AU - Macfarlane, S. AU - Mastwyk, M. AU - MacGregor, L. AU - Kiers, L. AU - Cherny, R. AU - Li, Q. X. AU - Tammer, A. PY - 2003 DA - 2003// TI - Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial JO - Arch Neurol VL - 60 UR - https://doi.org/10.1001/archneur.60.12.1685 DO - 10.1001/archneur.60.12.1685 ID - Ritchie2003 ER - TY - JOUR AU - Rogers, J. T. AU - Randall, J. D. AU - Eder, P. S. AU - Huang, X. AU - Bush, A. I. AU - Tanzi, R. E. AU - Venti, A. AU - Payton, S. M. AU - Giordano, T. AU - Nagano, S. PY - 2002 DA - 2002// TI - Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region JO - J Mol Neurosci VL - 19 UR - https://doi.org/10.1007/s12031-002-0014-6 DO - 10.1007/s12031-002-0014-6 ID - Rogers2002 ER - TY - JOUR AU - Payton, S. AU - Cahill, C. M. AU - Randall, J. D. AU - Gullans, S. R. AU - Rogers, J. T. PY - 2003 DA - 2003// TI - Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol JO - J Mol Neurosci VL - 20 UR - https://doi.org/10.1385/JMN:20:3:267 DO - 10.1385/JMN:20:3:267 ID - Payton2003 ER - TY - JOUR AU - Dedeoglu, A. AU - Cormier, K. AU - Payton, S. AU - Tseitlin, K. A. AU - Kremsky, J. N. AU - Lai, L. AU - Li, X. AU - Moir, R. D. AU - Tanzi, R. E. AU - Bush, A. I. PY - 2004 DA - 2004// TI - Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis JO - Exp Gerontol VL - 39 UR - https://doi.org/10.1016/j.exger.2004.08.016 DO - 10.1016/j.exger.2004.08.016 ID - Dedeoglu2004 ER - TY - JOUR AU - Ben-Shachar, D. AU - Kahana, N. AU - Kampel, V. AU - Warshawsky, A. AU - Youdim, M. B. H. PY - 2004 DA - 2004// TI - Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats JO - Neuropharmacology VL - 46 UR - https://doi.org/10.1016/j.neuropharm.2003.09.005 DO - 10.1016/j.neuropharm.2003.09.005 ID - Ben-Shachar2004 ER - TY - JOUR AU - Zheng, H. AU - Weiner, L. M. AU - Bar-Am, O. AU - Epsztejn, S. AU - Cabantchik, Z. I. AU - Warshawsky, A. AU - Youdim, M. B. AU - Fridkin, M. PY - 2005 DA - 2005// TI - Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases JO - Bioorg Med Chem VL - 13 UR - https://doi.org/10.1016/j.bmc.2004.10.037 DO - 10.1016/j.bmc.2004.10.037 ID - Zheng2005 ER - TY - JOUR AU - Avramovich-Tirosh, Y. AU - Amit, T. AU - Bar-Am, O. AU - Zheng, H. AU - Fridkin, M. AU - Youdim, M. B. H. PY - 2007 DA - 2007// TI - Therapeutic targets and potential of the novel brain-permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease JO - J Neurochem VL - 100 UR - https://doi.org/10.1111/j.1471-4159.2006.04258.x DO - 10.1111/j.1471-4159.2006.04258.x ID - Avramovich-Tirosh2007 ER - TY - JOUR AU - Guo, Q. AU - Zhao, B. AU - Li, M. AU - Shen, S. AU - Xin, W. PY - 1996 DA - 1996// TI - Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes JO - Biochimica et Biophysica Acta VL - 1304 UR - https://doi.org/10.1016/S0005-2760(96)00122-1 DO - 10.1016/S0005-2760(96)00122-1 ID - Guo1996 ER - TY - JOUR AU - Kumamoto, M. AU - Sonda, T. AU - Nagayama, K. AU - Tabata, M. PY - 2001 DA - 2001// TI - Effects of pH and metal ions on antioxidative activities of catechins JO - Biosci Biotechnol Biochem VL - 65 UR - https://doi.org/10.1271/bbb.65.126 DO - 10.1271/bbb.65.126 ID - Kumamoto2001 ER - TY - JOUR AU - Baum, L. AU - Ng, A. PY - 2004 DA - 2004// TI - Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models JO - J Alzheimers Dis VL - 6 ID - Baum2004 ER - TY - CHAP AU - Mandel, S. AU - Weinreb, O. AU - Reznichenko, L. AU - Kalfon, L. AU - Amit, T. PY - 2006 DA - 2006// TI - Green tea catechins as brain-permeable, non toxic iron chelators to 'iron out iron' from the brain BT - J Neural Transm ID - Mandel2006 ER - TY - JOUR AU - Reznichenko, L. AU - Amit, T. AU - Zheng, H. AU - Avramovich-Tirosh, Y. AU - Youdim, M. B. AU - Weinreb, O. AU - Mandel, S. PY - 2006 DA - 2006// TI - Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease JO - J Neurochem VL - 97 UR - https://doi.org/10.1111/j.1471-4159.2006.03770.x DO - 10.1111/j.1471-4159.2006.03770.x ID - Reznichenko2006 ER - TY - JOUR AU - Rezai-Zadeh, K. AU - Shytle, D. AU - Sun, N. AU - Mori, T. AU - Hou, H. AU - Jeanniton, D. AU - Ehrhart, J. AU - Townsend, K. AU - Zeng, J. AU - Morgan, D. PY - 2005 DA - 2005// TI - Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice JO - J Neurosci VL - 25 UR - https://doi.org/10.1523/JNEUROSCI.1521-05.2005 DO - 10.1523/JNEUROSCI.1521-05.2005 ID - Rezai-Zadeh2005 ER - TY - JOUR AU - Avramovich-Tirosh, Y. AU - Reznichenko, L. AU - Amit, T. AU - Zheng, H. AU - Fridkin, M. AU - Mandel, S. AU - Youdim, M. B. H. PY - 2007 DA - 2007// TI - Neurorescue activity, APP regulation and amyloid- peptide reduction by novel multi-functional brain permeable iron- chelator- antioxidants, M-30 and green tea polyphenol, EGCG JO - Curr Alzheimer Res VL - 4 UR - https://doi.org/10.2174/156720507781788927 DO - 10.2174/156720507781788927 ID - Avramovich-Tirosh2007 ER - TY - JOUR AU - Bandyopadhyay, S. AU - Ni, J. AU - Ruggiero, A. AU - Walshe, K. AU - Rogers, M. S. AU - Chattopadhyay, N. AU - Glicksman, M. A. AU - Rogers, J. T. PY - 2006 DA - 2006// TI - A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA JO - J Biomol Screen VL - 11 UR - https://doi.org/10.1177/1087057106287271 DO - 10.1177/1087057106287271 ID - Bandyopadhyay2006 ER - TY - JOUR AU - Copani, A. AU - Condorelli, F. AU - Caruso, A. AU - Vancheri, C. AU - Sala, A. AU - Giuffrida Stella, A. M. AU - Canonico, P. L. AU - Nicoletti, F. AU - Sortino, M. A. PY - 1999 DA - 1999// TI - Mitotic signaling by beta-amyloid causes neuronal death JO - FASEB J VL - 13 ID - Copani1999 ER - TY - JOUR AU - Giovanni, A. AU - Wirtz-Brugger, F. AU - Keramaris, E. AU - Slack, R. AU - Park, D. S. PY - 1999 DA - 1999// TI - Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in B-amyloid-induced neuronal death JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.27.19011 DO - 10.1074/jbc.274.27.19011 ID - Giovanni1999 ER - TY - JOUR AU - Wu, Q. AU - Combs, C. AU - Cannady, S. B. AU - Geldmacher, D. S. AU - Herrup, K. PY - 2000 DA - 2000// TI - Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons JO - Neurobiol Aging VL - 21 UR - https://doi.org/10.1016/S0197-4580(00)00219-0 DO - 10.1016/S0197-4580(00)00219-0 ID - Wu2000 ER - TY - JOUR AU - Reznichenko, L. AU - Amit, T. AU - Youdim, M. B. AU - Mandel, S. PY - 2005 DA - 2005// TI - Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth JO - J Neurochem VL - 93 UR - https://doi.org/10.1111/j.1471-4159.2005.03085.x DO - 10.1111/j.1471-4159.2005.03085.x ID - Reznichenko2005 ER - TY - JOUR AU - Friedlich, A. L. AU - Tanzi, R. E. AU - Rogers, J. T. PY - 2007 DA - 2007// TI - The 5'-untranslated region of Parkinson's disease alpha-synuclein messenger RNA contains a predicted iron responsive element JO - Mol Psychiatry VL - 12 UR - https://doi.org/10.1038/sj.mp.4001937 DO - 10.1038/sj.mp.4001937 ID - Friedlich2007 ER - TY - JOUR AU - Tucker, S. AU - Ahl, M. AU - Bush, A. AU - Westaway, D. AU - Huang, X. AU - Rogers, J. T. PY - 2005 DA - 2005// TI - Pilot study of the reducing effect on amyloidosis in vivoby three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region JO - Curr Alzheimer Res VL - 2 UR - https://doi.org/10.2174/1567205053585855 DO - 10.2174/1567205053585855 ID - Tucker2005 ER - TY - JOUR AU - Shaw, K. T. AU - Utsuki, T. AU - Rogers, J. AU - Yu, Q. S. AU - Sambamurti, K. AU - Brossi, A. AU - Ge, Y. W. AU - Lahiri, D. K. AU - Greig, N. H. PY - 2001 DA - 2001// TI - Phenserine regulates translation of beta-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development JO - Proc Natl Acad Sci USA VL - 98 UR - https://doi.org/10.1073/pnas.131152998 DO - 10.1073/pnas.131152998 ID - Shaw2001 ER -