Skip to main content

Table 1 Summary of inhibitiory constants for angiotensin IV and LVV-hemorphin 7 and their analogues for IRAP

From: Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

Angiotensin IV and analogues
  Reference Ki (nM) *
   Val-Tyr-Ile-His-Pro-Phe [21] 113
   Nle-Tyr-Ile-His-Pro-Phe [21] 340
   Val-Tyr-Ile-Cys-Pro-Cys [49] 25.8†
   Val-Tyr-Ile-[AMPAA] [49] 43.6†
   Valψ(CH2NH2)-Tyr-Valψ(CH2NH2)-His-Pro-Phe (divalinal-AT4) [21] 2300
   β2hVal-Tyr-Ile-His-Pro-Phe [51] 26‡
LVV-hemorphin 7 and analogues
   Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe [48] 196
   Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe [21] 845
   Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe [48] 56
   Leu-Val-Val-Tyr-Pro-Trp-Thr [48] 560
   Val-Tyr-Pro-Trp-Thr [48] 112
   Val-Tyr-Pro [48] 620
  1. *Data obtained using HEK293 cells transiently transfected with insulin-regulated aminopeptidase and L-Leu-pNA as substrate. †Comparative angiotensin IV Ki data not reported. ‡Angiotensin IV Ki reported as 56 nM in this assay.
Back to article page