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Table 1 Effects of A1R activation on population burst parameters

From: Rhythm generation by the pre-Bötzinger Complex in medullary slice and island preparations: Effects of adenosine A1receptor activation

    Slice    Island  
Treatment Group Stage of Experiment n Frequency
(bursts·sec-1)
Amplitude n Frequency
(bursts·sec-1)
Amplitude
aCSF control 1. Baseline 12 0.33 ± 0.02 2.01 ± 0.24 9 0.37 ± 0.04 1.39 ± 0.25
  2. aCSF   0.33 ± 0.03 2.03 ± 0.25   0.36 ± 0.04 1.50 ± 0.31
  3. NCPA   0.24 ± 0.03 2.13 ± 0.24   0.26 ± 0.04a, b 1.57 ± 0.40
  4. DPCPX   0.31 ± 0.02 1.81 ± 0.22   0.37 ± 0.03 1.48 ± 0.44
Bicuculline 1. Baseline 11 0.36 ± 0.03 1.65 ± 0.23 7 0.44 ± 0.06 1.13 ± 0.19
  2. Bicuculline   0.33 ± 0.02 2.27 ± 0.35a   0.43 ± 0.05 1.77 ± 0.29a
  3. NCPA   0.22 ± 0.03a, b 2.33 ± 0.35a   0.41 ± 0.05 1.55 ± 0.21a
  4. DPCPX   0.31 ± 0.03 1.93 ± 0.30   0.48 ± 0.07 1.81 ± 0.37a
Gabazine 1. Baseline 7 0.34 ± 0.07 3.10 ± 1.14 6 0.27 ± 0.04 0.89 ± 0.10
  2. Gabazine   0.33 ± 0.06 3.48 ± 1.24   0.29 ± 0.03 0.86 ± 0.10
  3. NCPA   0.25 ± 0.07a, b 2.56 ± 0.89   0.18 ± 0.05a, b 0.89 ± 0.15
  4. DPCPX   0.32 ± 0.06 3.37 ± 1.11   0.30 ± 0.05 0.76 ± 0.09
Gabazine & Strychnine 1. Baseline 8 0.33 ± 0.05 0.97 ± 0.16 6 0.40 ± 0.06 1.15 ± 0.16
  2. Gabazine + Strychnine   0.30 ± 0.04 1.40 ± 0.20   0.40 ± 0.05 1.46 ± 0.23a
  3. NCPA   0.24 ± 0.03a, b 1.31 ± 0.23   0.34 ± 0.05 1.51 ± 0.26a
  4. DPCPX   0.30 ± 0.03 1.10 ± 0.17   0.38 ± 0.04 1.45 ± 0.26a
  1. Slices were superfused with one of four solutions prior to treatment with NCPA (aCSF alone, aCSF with bicuculline, aCSF with gabazine, or aCSF with gabazine and strychnine).
  2. 1All values presented as mean ± SEM.
  3. aDifferent from baseline (pre-treatment) value at P < 0.05 (Tukey post-hoc tests)
  4. bDifferent from control (aCSF only) at P < 0.05 (Tukey post-hoc tests)