Figure 1
Effects of A 1 R activation on preBötC rhythmogenesis in medullary slice preparations. A. Representative effects of bath-applied NCPA (1 μM) alone, NCPA in the presence of gabazine (20 μM), or NCPA in combination with gabazine (20 μM) and strychnine (1 μM). B. Whether applied (i) alone, (ii) with gabazine, or (iii) with gabazine and strychnine, NCPA decreased burst frequency (a, value different from baseline at P < 0.05, Tukey post-hoc test; b, value different from step 2 of treatment – either continued aCSF, application of gabazine, or application of gabazine and strychnine – at P < 0.05, Tukey post-hoc test).