Table 3 Significant differentially expressed probesets from five ExpG eyes compared to eight control eyes by microarray.
PROBESET | Definition | Group fold change | Representative public ID | Gene title | Gene symbol | RP | SAM | ONH astrocyte | RGC |
|---|---|---|---|---|---|---|---|---|---|
Hs.103291 | HS, PT | 1.79 ± 0.68 | NM_016588 | neuritin 1 | NRN1 | 0.00 | 0.01 | NA | Y |
Hs.12333 | HS, PT | -1.69 ± 0.25 | NM_007282 | ring finger protein 13 | RNF13 | 0.03 | 0.01 | Y | NA |
Hs.134974 | HS, PT | 1.70 ± 0.37 | NM_002045 | growth associated protein 43 | GAP43 | 0.06 | 0.01 | N | Y |
Hs.155097 | HS, PT | -1.62 ± 0.49 | M36532 | carbonic anhydrase II | CA2 | 0.05 | 0.11 | N | NA |
Hs.155247 | HS | -2.37 ± 0.94 | NM_005165 | aldolase C, fructose-bisphosphate | ALDOC | 0.00 | 0.01 | Y | Y |
Hs.165636 | HS, PT | 1.88 ± 0.54 | NM_017594 | DIRAS family, GTP-binding RAS-like 2 | DIRAS2 | 0.00 | 0.00 | NA | NA |
Hs.198760 | HS | 8.37 ± 4.66 | X15306 | neurofilament, heavy polypeptide 200 kDa | NEFH | 0.00 | 0.00 | N | Y |
Hs.233240 | HS, PT | 1.66 ± 0.60 | NM_004369 | collagen, type VI, alpha 3 | COL6A3 | 0.03 | 0.11 | Y | NA |
Hs.235873 | HS, PT | -1.61 ± 0.48 | NM_024897 | progestin and adipoQ receptor family member VI | PAQR6 | 0.01 | 0.08 | NA | NA |
Hs.277035 | HS | 1.48 ± 0.20 | BC006230 | monoglyceride lipase | MGLL | 0.31 | 0.01 | Y | NA |
Hs.308709 | HS | -2.22 ± 0.88 | NM_005313 | protein disulfide isomerase, family A, member 3 | PDIA3 | 0.03 | 0.15 | Y | NA |
Hs.351279 | HS, PT | 1.90 ± 0.56 | X76775 | major histocompatibility complex, class II, DM alpha | HLA-DMA | 0.02 | 0.01 | N | NA |
Hs.369397 | HS, PT | 1.63 ± 0.32 | NM_000358 | transforming growth factor, beta-induced, 68 kDa | TGFBI | 0.05 | 0.00 | Y | NA |
Hs.378901 | HS, PT | -1.49 ± 0.30 | NM_014717 | zinc finger protein 536 | ZNF536 | 0.06 | 0.03 | N | NA |
Hs.412355 | HS | 1.82 ± 0.83 | NM_001492 | growth differentiation factor 1/LAG1 homolog, ceramide synthase 1 | GDF1/LASS1 | 0.01 | 0.08 | Y | NA |
Hs.435557 | HS, PT | -1.75 ± 0.39 | BF059313 | kinesin family member 5C | KIF5C | 0.02 | 0.00 | N | NA |
Hs.443625 | HS, PT | 2.01 ± 0.63 | NM_000090 | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | COL3A1 | 0.01 | 0.01 | Y | NA |
Hs.458573 | HS, PT | 1.47 ± 0.20 | NM_006207 | platelet-derived growth factor receptor-like | PDGFRL | 0.15 | 0.00 | Y | NA |
Hs.478153 | HS, PT | -1.62 ± 0.45 | NM_005025 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | SERPINI1 | 0.03 | 0.14 | Y | Y |
Hs.483444 | HS | 1.60 ± 0.49 | AF144103 | chemokine (C-X-C motif) ligand 14 | CXCL14 | 0.03 | 0.07 | NA | NA |
Hs.485130 | HS | 1.79 ± 0.52 | NM_002121 | major histocompatibility complex, class II, DP beta 1 | HLA-DPB1 | 0.03 | 0.02 | Y | NA |
Hs.489142 | HS, PT | 1.62 ± 0.42 | NM_000089 | collagen, type I, alpha 2 | COL1A2 | 0.03 | 0.01 | Y | NA |
Hs.48924 | HS | -1.85 ± 0.46 | NM_014782 | armadillo repeat containing, X-linked 2 | ARMCX2 | 0.03 | 0.03 | Y | NA |
Hs.496622 | HS, PT | -1.80 ± 0.41 | NM_005032 | plastin 3 (T isoform) | PLS3 | 0.03 | 0.03 | Y | NA |
Hs.515354 | HS | -1.73 ± 0.58 | NM_002361 | myelin-associated glycoprotein | MAG | 0.05 | 0.23 | Y | NA |
Hs.515369 | HS | 1.77 ± 0.55 | NM_003332 | TYRO protein tyrosine kinase binding protein | TYROBP | 0.03 | 0.14 | N | NA |
Hs.518525 | HS | -1.60 ± 0.30 | NM_002065 | glutamate-ammonia ligase (glutamine synthetase) | GLUL | 0.07 | 0.00 | Y | NA |
Hs.520048 | HS | 1.50 ± 0.56 | M60333 | major histocompatibility complex, class II, DR alpha | HLA-DRA | 0.03 | 0.51 | Y | NA |
Hs.529571 | HS, PT | 1.63 ± 0.44 | NM_002899 | retinol binding protein 1, cellular | RBP1 | 0.02 | 0.03 | Y | Y |
Hs.550276 | HS, PT | 1.59 ± 0.23 | NA | NA | NA | 0.07 | 0.00 | Y | NA |
Hs.70327 | HS | 1.68 ± 0.38 | NM_001311 | cysteine-rich protein 1 (intestinal) | CRIP1 | 0.03 | 0.01 | Y | NA |
Hs.88778 | HS, PT | -1.90 ± 0.44 | BC002511 | carbonyl reductase 1 | CBR1 | 0.03 | 0.01 | Y | NA |
Hs.109225 | PT | 1.58 ± 1.42 | NM_001078 | vascular cell adhesion molecule 1 | VCAM1 | 0.04 | 0.48 | Y | NA |
Hs.144197 | PT | -1.74 ± 0.50 | NM_003360 | UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase) | UGT8 | 0.02 | 0.06 | N | NA |
Hs.190495 | PT | 6.78 ± 4.64 | NM_002510 | glycoprotein (transmembrane) nmb | GPNMB | 0.00 | 0.01 | Y | Y |
Hs.388664 | PT | 1.53 ± 0.50 | NM_000975 | ribosomal protein L11 | RPL11 | 0.03 | 0.47 | Y | NA |
Hs.502235 | PT | 2.30 ± 1.03 | NA | NA | NA | 0.01 | 0.02 | Y | Y |
Hs.518773 | PT | -2.22 ± 0.58 | BF448062 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | UBE2D3 | 0.04 | 0.01 | Y | NA |
Hs.530902 | PT | 1.63 ± 0.42 | NM_005849 | immunoglobulin superfamily, member 6 | IGSF6 | 0.10 | 0.02 | N | NA |
Hs.532768 | PT | 1.60 ± 0.39 | NM_002615 | pigment epithelium derived factor/serpin peptidase inhibitor, clade F, member 1 | PEDF/SERPINF1 | 0.13 | 0.02 | Y | NA |
Hs.58414 | PT | 1.69 ± 0.63 | NM_001458 | filamin C, gamma (actin binding protein 280) | FLNC | 0.04 | 0.09 | Y | NA |
Hs.75285 | PT | 1.49 ± 0.39 | NM_002216 | inter-alpha (globulin) inhibitor H2 | ITIH2 | 0.05 | 0.03 | N | NA |