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Figure 3 | BMC Neuroscience

Figure 3

From: Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension

Figure 3

Expression of GPNMB in experimental glaucoma in sagittal sections of the ONH (Macaque #3; Supplemental Table 3). (A) Low expression of GPNMB (red) in the retinal ganglion cell layer (GCL) and nerve fiber layer (NFL) in control monkey eye. Granular staining of GPNMB is present in the area adjacent to the inner limiting membrane (ILM). Very low staining for GFAP (green) is observed in the normal nerve fiber layer. Nuclei are stained with DAPI. (B) Upregulation of GPNMB in retinal ganglion cells (GCL) and in axons and retinal astrocytes in the nerve fiber layer in ExpG. Notice marked increase in GFAP staining in the nerve fiber layer. A, B: Magnification bar = 25 μm. (C) Low expression of GPMNB in astrocytes and axons in the normal monkey optic nerve head. (D) Marked upregulation of GPNMB in axons in the nerve bundles (NB) and in GFAP+ astrocytes (green) in the lamina cribrosa (LC) and glial columns (GC). Note that GPNMB appears to localize to the nucleus and cytoplasm in astrocytes in ExpG. C, D: Magnification bar = 40 μm. (E and F) Low expression of GPNMB associated with astrocytes and axons in the post laminar optic nerve. (E, Control; F, ExpG). E, F: Magnification bar = 40 μm.

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