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Figure 6 | BMC Neuroscience

Figure 6

From: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors

Figure 6

(A-C) Recombinant α-syn (Wt, A30P and A53T) were incubated with ATP (1 mM), ATPγS (3 mM), Ca2+ (1 mM), ATP/Ca2+ or ATPγS/Ca2+ in absence or presence of 1.5 mg/ml of KO cytosol, for 10 min at 37°C. Incubation with ATP (Student's T-test, p < 0.001), but not ATPγS or Ca++ (Student's T-test, p > 0.05), induced a significant increase in the binding of Wt and mutant forms of α-syn (compared to control condition without added cofactors).

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