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Table 1 Patient Group and Subgroup Description

From: Serum anticholinergic activity and cerebral cholinergic dysfunction: An EEG study in frail elderly with and without delirium

(mean ± SD) Cognitively Unimpaired
n = 15
Dementia
n = 31
Delirium with Dementia
n = 15
All patients
n = 61
Statistics
Age 86.9 ± 4.0 86.3 ± 4.8 85.3 ± 4.6 86.2 ± 4.5 F(2,58) = 0,46; p = 0,44
CIRS 26.6 ± 4.8 30.5 ± 4.4 31.7 ± 5.5 29.9 ± 4.9 F(2,58) = 0,74; p = 0,48
Dementia type (n)
AD/mixed/VaD
--- 19/9/3 61/29/10% 9/5/1 60/33/7% 28/14/4 61/29/8% *  
Medication amount
(Median, range)
5.1 ± 2.7
(5.0; 1–12)
5.3 ± 2.5
(5.0; 1–10)
5.7 ± 2.3
(6.0; 3–9)
5.4 ± 2.5
(5.0; 1–12)
F(2,58) = 0,23; p = 0,79
delirogenic medication
(Median, range)
1.6 ± 1.6
(1.0; 0–4)
1.8 ± 1.1
(2.0; 0–4)
2.5 ± 1.4
(2.0; 0–5)
1.9 ± 1.3
(2.0; 0–5)
F(2,58) = 0,20; p = 0,15
Acute Infection 1/7% 7/22% 3/20% 11/18% H (2,61) = 1.755; p = 0.42
days in hospital 20.5 ± 17.1 15.1 ± 6.8 18.1 ± 7.2 17.2 ± 10.4 F(2,58) = 1,43; p = 0,25
Barthel admission 62.5 ± 31.2 33.7 ± 24.3 45.0 ± 18.1 43.9 ± 27.2 F(2,52) = 6.17; p < 0.005
CU >> D; CU > DD
-ADL discharge 75.8 ± 29.0 47.7 ± 31.7 61.7 ± 25.1 59.0 ± 31.2 F(2,44) = 3.78; p < 0.05
CU > D
IQCODE (norm < 3.3) 3.1 ± 0.2 4.2 ± 0.6 4.2 ± 0.7 4.2 ± 0.7 F(2,43) = 3.93; p < 0.03
CU < D, CU < DD
Delirium Index
(range 0 – 21)
2.5 ± 0.7 6.2 ± 4.0 8.7 ± 4.5 6.4 ± 1.1 H (2, 46) = 7,15 p =,028
CU < D < DD
MMSE (norm > 28 P) 28.8 ± 1.8 16.7 ± 7.5 14.4 ± 6.0 19.1 ± 8.3 H (2,61) = 32.52; p < 0.001
CU >> D; CU >> DD
SPMSQ (norm < 2) 0.6 ± 0.9 4.7 ± 2.8 6.4 ± 2.7 4.1 ± 3.2 H(2,60) = 27.24; p < 0.0001
CU << D, CU << DD
SAA in pmol/ml
(w/o extremes > 2SD)
9.33 ± 4.44
(9.33 ± 4.44)
11.03 ± 6.15
(10.27 ± 4.62)
12.25 ± 10.53
(9.77 ± 4.47)
10.91 ± 7.12
(9.91 ± 4.48)
F(2,57) = 0,71; p = 0,50
F(2,55) = 0,62; p = 0,54
  1. Mean ± SD are shown. AD = Alzheimer Dementia, mixed = AD with vascular pathology, VaD = Vascular Dementia, SAA = Serum Anticholinergic Activity,. CIRS = Cumulative Illness Rating Scale, IQCODE = Informant Questionnaire on Cognitive Decline, SPMSQ = Short Portable Mental Status Questionnaire, MMSE = Mini Mental State Examination, Barthel-ADL = Activities of Daily Living. * n = 46 demented patients ANOVA/Kruskal-Willis statistics and posthoc-testing, with < or > giving the direction of the difference at a significance level of p < 0.01; >> or << specifies direction at a higher significance level of p < 0.001