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Table 2 Qualitative assessment of pathological progression by region in male 2–26 month-old 3xTg-AD mice.

From: Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice

Antigen

Age (months)

hAPP

2

3

6

9

12

15

18

26

Primary motor cortex

+

+

+

+

+

+

+

+

Amygdala

-

-

+

+

++

++

++

++

Rostral Hippocampus CA1

+

+

+

+

++

++

++

++

Medial Hippocampus CA1

+

+

+

+

++

++

++

++

Caudal Hippocampus CA1/Subiculum

+

+

+

+

++

++

++

++

Entorhinal Cortex

+

+

+

+

++

++

++

++

hAPP/Aβ

        

Primary motor cortex

+

+

++

++

++

++

+++

+++

Amygdala

+

+

++

++

++

++

+++

+++

Rostral Hippocampus CA1

-

-

+

+

++

++

+++

+++

Medial Hippocampus CA1

-

-

+

+

++

++

+++

+++

Caudal Hippocampus CA1/Subiculum

-

+

+

+

++

+++

+++

+++

Entorhinal Cortex

-

-

+

+

+

+

+++

+++

hAβ 1–42 (Extracellular)

        

Primary motor cortex

-

-

-

-

-

-

+

++

Amygdala

-

-

-

-

-

-

++

+++

Rostral Hippocampus CA1

-

-

-

-

-

-

+

++

Medial Hippocampus CA1

-

-

-

-

-

-

+

++

Caudal Hippocampus CA1/Subiculum

-

-

-

-

-

+

++

+++

Entorhinal Cortex

-

-

-

-

-

-

+

+++

hAβ 1–42 (Intracellular)

        

Primary motor cortex

+/-

+/-

+

+

++

++

++

++

Amygdala

+/-

+/-

+

+

++

++

++

++

Rostral Hippocampus CA1

+/-

+

++

++

++

++

++

++

Medial Hippocampus CA1

+

++

++

++

++

++

++

++

Caudal Hippocampus CA1/Subiculum

+

++

++

++

++

++

++

++

Entorhinal Cortex

+/-

+

+

+

+

+

+

+

Human Tau

        

Primary motor cortex

+/-

+

+

+

+

+

+

+

Amygdala

-

-

+

+

+

+

+

+

Rostral Hippocampus CA1

+/-

+/-

+

+

+

+

+

+

Medial Hippocampus CA1

+/-

+/-

+

+

+

+

++

++

Caudal Hippocampus CA1/Subiculum

+/-

+/-

+

+

+

+

++

++

Entorhinal Cortex

-

-

-

-

-

+/-

+/-

+/-

Phospho-hTau (Thr231)

        

Primary motor cortex

-

-

-

+

+

+/-

+/-

+

Amygdala

-

-

+

++

++

+

+

++

Rostral Hippocampus CA1

-

-

+/-

+

+

+/-

+/-

+

Medial Hippocampus CA1

-

-

+/-

+

+

+

+/-

++

Caudal Hippocampus CA1/Subiculum

-

-

+

+

+

+

+

+

Entorhinal Cortex

-

-

-

-

-

-

-

+/-

Paired Helical Filaments

        

Primary motor cortex

-

-

-

-

-

-

-

-

Amygdala

-

-

-

-

-

-

-

-

Rostral Hippocampus CA1

-

-

-

-

-

-

+/-

+

Medial Hippocampus CA1

-

-

-

-

-

-

+/-

+

Caudal Hippocampus CA1/Subiculum

-

-

-

-

-

-

+

+

Entorhinal Cortex

-

-

-

-

-

-

-

+/-

Microglia

        

Primary motor cortex

+

+

+

+

+

+

++

++

Amygdala

+

+

+

+

+

+

+

++

Rostral Hippocampus CA1

+

+

++

++

++

++

++

++

Medial Hippocampus CA1

+

+

++

++

++

++

++

++

Caudal Hippocampus CA1/Subiculum

+

+

++

++

++

++

+++

+++

Entorhinal Cortex

+

+

++

++

++

++

++

++

Astrocytes

        

Primary motor cortex

+

+

+

+

+

+

+

+

Amygdala

+/-

+/-

+/-

+/-

+/-

+/-

+/-

+/-

Rostral Hippocampus CA1

+

+

+

+

+

+

+

+

Medial Hippocampus CA1

+

+

+

+

+

+

+

+

Caudal Hippocampus CA1/Subiculum

+

+

+

+

+

+

+

+

Entorhinal Cortex

+

+

+

+

+

+

+

+