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Table 2 Qualitative assessment of pathological progression by region in male 2–26 month-old 3xTg-AD mice.

From: Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice

Antigen Age (months)
hAPP 2 3 6 9 12 15 18 26
Primary motor cortex + + + + + + + +
Amygdala - - + + ++ ++ ++ ++
Rostral Hippocampus CA1 + + + + ++ ++ ++ ++
Medial Hippocampus CA1 + + + + ++ ++ ++ ++
Caudal Hippocampus CA1/Subiculum + + + + ++ ++ ++ ++
Entorhinal Cortex + + + + ++ ++ ++ ++
hAPP/Aβ         
Primary motor cortex + + ++ ++ ++ ++ +++ +++
Amygdala + + ++ ++ ++ ++ +++ +++
Rostral Hippocampus CA1 - - + + ++ ++ +++ +++
Medial Hippocampus CA1 - - + + ++ ++ +++ +++
Caudal Hippocampus CA1/Subiculum - + + + ++ +++ +++ +++
Entorhinal Cortex - - + + + + +++ +++
hAβ 1–42 (Extracellular)         
Primary motor cortex - - - - - - + ++
Amygdala - - - - - - ++ +++
Rostral Hippocampus CA1 - - - - - - + ++
Medial Hippocampus CA1 - - - - - - + ++
Caudal Hippocampus CA1/Subiculum - - - - - + ++ +++
Entorhinal Cortex - - - - - - + +++
hAβ 1–42 (Intracellular)         
Primary motor cortex +/- +/- + + ++ ++ ++ ++
Amygdala +/- +/- + + ++ ++ ++ ++
Rostral Hippocampus CA1 +/- + ++ ++ ++ ++ ++ ++
Medial Hippocampus CA1 + ++ ++ ++ ++ ++ ++ ++
Caudal Hippocampus CA1/Subiculum + ++ ++ ++ ++ ++ ++ ++
Entorhinal Cortex +/- + + + + + + +
Human Tau         
Primary motor cortex +/- + + + + + + +
Amygdala - - + + + + + +
Rostral Hippocampus CA1 +/- +/- + + + + + +
Medial Hippocampus CA1 +/- +/- + + + + ++ ++
Caudal Hippocampus CA1/Subiculum +/- +/- + + + + ++ ++
Entorhinal Cortex - - - - - +/- +/- +/-
Phospho-hTau (Thr231)         
Primary motor cortex - - - + + +/- +/- +
Amygdala - - + ++ ++ + + ++
Rostral Hippocampus CA1 - - +/- + + +/- +/- +
Medial Hippocampus CA1 - - +/- + + + +/- ++
Caudal Hippocampus CA1/Subiculum - - + + + + + +
Entorhinal Cortex - - - - - - - +/-
Paired Helical Filaments         
Primary motor cortex - - - - - - - -
Amygdala - - - - - - - -
Rostral Hippocampus CA1 - - - - - - +/- +
Medial Hippocampus CA1 - - - - - - +/- +
Caudal Hippocampus CA1/Subiculum - - - - - - + +
Entorhinal Cortex - - - - - - - +/-
Microglia         
Primary motor cortex + + + + + + ++ ++
Amygdala + + + + + + + ++
Rostral Hippocampus CA1 + + ++ ++ ++ ++ ++ ++
Medial Hippocampus CA1 + + ++ ++ ++ ++ ++ ++
Caudal Hippocampus CA1/Subiculum + + ++ ++ ++ ++ +++ +++
Entorhinal Cortex + + ++ ++ ++ ++ ++ ++
Astrocytes         
Primary motor cortex + + + + + + + +
Amygdala +/- +/- +/- +/- +/- +/- +/- +/-
Rostral Hippocampus CA1 + + + + + + + +
Medial Hippocampus CA1 + + + + + + + +
Caudal Hippocampus CA1/Subiculum + + + + + + + +
Entorhinal Cortex + + + + + + + +