Antigen | Age (months) | |||||||
---|---|---|---|---|---|---|---|---|
hAPP | 2 | 3 | 6 | 9 | 12 | 15 | 18 | 26 |
Primary motor cortex | + | + | + | + | + | + | + | + |
Amygdala | - | - | + | + | ++ | ++ | ++ | ++ |
Rostral Hippocampus CA1 | + | + | + | + | ++ | ++ | ++ | ++ |
Medial Hippocampus CA1 | + | + | + | + | ++ | ++ | ++ | ++ |
Caudal Hippocampus CA1/Subiculum | + | + | + | + | ++ | ++ | ++ | ++ |
Entorhinal Cortex | + | + | + | + | ++ | ++ | ++ | ++ |
hAPP/Aβ |  |  |  |  |  |  |  |  |
Primary motor cortex | + | + | ++ | ++ | ++ | ++ | +++ | +++ |
Amygdala | + | + | ++ | ++ | ++ | ++ | +++ | +++ |
Rostral Hippocampus CA1 | - | - | + | + | ++ | ++ | +++ | +++ |
Medial Hippocampus CA1 | - | - | + | + | ++ | ++ | +++ | +++ |
Caudal Hippocampus CA1/Subiculum | - | + | + | + | ++ | +++ | +++ | +++ |
Entorhinal Cortex | - | - | + | + | + | + | +++ | +++ |
hAβ 1–42 (Extracellular) |  |  |  |  |  |  |  |  |
Primary motor cortex | - | - | - | - | - | - | + | ++ |
Amygdala | - | - | - | - | - | - | ++ | +++ |
Rostral Hippocampus CA1 | - | - | - | - | - | - | + | ++ |
Medial Hippocampus CA1 | - | - | - | - | - | - | + | ++ |
Caudal Hippocampus CA1/Subiculum | - | - | - | - | - | + | ++ | +++ |
Entorhinal Cortex | - | - | - | - | - | - | + | +++ |
hAβ 1–42 (Intracellular) |  |  |  |  |  |  |  |  |
Primary motor cortex | +/- | +/- | + | + | ++ | ++ | ++ | ++ |
Amygdala | +/- | +/- | + | + | ++ | ++ | ++ | ++ |
Rostral Hippocampus CA1 | +/- | + | ++ | ++ | ++ | ++ | ++ | ++ |
Medial Hippocampus CA1 | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ |
Caudal Hippocampus CA1/Subiculum | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ |
Entorhinal Cortex | +/- | + | + | + | + | + | + | + |
Human Tau | Â | Â | Â | Â | Â | Â | Â | Â |
Primary motor cortex | +/- | + | + | + | + | + | + | + |
Amygdala | - | - | + | + | + | + | + | + |
Rostral Hippocampus CA1 | +/- | +/- | + | + | + | + | + | + |
Medial Hippocampus CA1 | +/- | +/- | + | + | + | + | ++ | ++ |
Caudal Hippocampus CA1/Subiculum | +/- | +/- | + | + | + | + | ++ | ++ |
Entorhinal Cortex | - | - | - | - | - | +/- | +/- | +/- |
Phospho-hTau (Thr231) | Â | Â | Â | Â | Â | Â | Â | Â |
Primary motor cortex | - | - | - | + | + | +/- | +/- | + |
Amygdala | - | - | + | ++ | ++ | + | + | ++ |
Rostral Hippocampus CA1 | - | - | +/- | + | + | +/- | +/- | + |
Medial Hippocampus CA1 | - | - | +/- | + | + | + | +/- | ++ |
Caudal Hippocampus CA1/Subiculum | - | - | + | + | + | + | + | + |
Entorhinal Cortex | - | - | - | - | - | - | - | +/- |
Paired Helical Filaments | Â | Â | Â | Â | Â | Â | Â | Â |
Primary motor cortex | - | - | - | - | - | - | - | - |
Amygdala | - | - | - | - | - | - | - | - |
Rostral Hippocampus CA1 | - | - | - | - | - | - | +/- | + |
Medial Hippocampus CA1 | - | - | - | - | - | - | +/- | + |
Caudal Hippocampus CA1/Subiculum | - | - | - | - | - | - | + | + |
Entorhinal Cortex | - | - | - | - | - | - | - | +/- |
Microglia | Â | Â | Â | Â | Â | Â | Â | Â |
Primary motor cortex | + | + | + | + | + | + | ++ | ++ |
Amygdala | + | + | + | + | + | + | + | ++ |
Rostral Hippocampus CA1 | + | + | ++ | ++ | ++ | ++ | ++ | ++ |
Medial Hippocampus CA1 | + | + | ++ | ++ | ++ | ++ | ++ | ++ |
Caudal Hippocampus CA1/Subiculum | + | + | ++ | ++ | ++ | ++ | +++ | +++ |
Entorhinal Cortex | + | + | ++ | ++ | ++ | ++ | ++ | ++ |
Astrocytes | Â | Â | Â | Â | Â | Â | Â | Â |
Primary motor cortex | + | + | + | + | + | + | + | + |
Amygdala | +/- | +/- | +/- | +/- | +/- | +/- | +/- | +/- |
Rostral Hippocampus CA1 | + | + | + | + | + | + | + | + |
Medial Hippocampus CA1 | + | + | + | + | + | + | + | + |
Caudal Hippocampus CA1/Subiculum | + | + | + | + | + | + | + | + |
Entorhinal Cortex | + | + | + | + | + | + | + | + |