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Table 3 Summary of furosemide effects on synaptic responses vs. anatomical location of stimulation site.

From: Slow GABAAmediated synaptic transmission in rat visual cortex

 

control

furosemide

n

amplitude

   

   basal

95 (71, 203) pA

39 (34, 66) pA

9

   apical

114 (73, 181) pA

28 (20, 58) pA

12

   distal

68 (60, 85) pA

113 (85, 133) pA

8

rise time

   

   basal

2.8 (2.7, 4.5) ms

10.2 (6.9, 10.4) ms

9

   apical

3.3 (2.4, 4.1) ms

5.3 (4.1, 7.8) ms

12

   distal

6.6 (4.3, 9.2) ms

6.0 (5.1, 8.2) ms

8

decay time constant, Ï„1

   

   basal

18.5 (13.5, 31.0) ms

47.2 (40.0, 73.0) ms

9

   apical

13.8 (12.5, 17.0) ms

31.1 (20.4, 34.7) ms

12

   distal

28.1 (21.6, 39.7) ms

39.3 (28.5, 59.5) ms

8

  1. Median values for control and furosemide groups are shown with the first and third quartiles indicated in parentheses. Stimulation sites were grouped according to their proximity to the basal (basal), proximal apical (apical), or the distal apical (distal) dendritic region of each pyramidal neuron. The decay time constants were estimated from the double exponential fits to the IPSC decaying response phase.
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BMC Neuroscience

ISSN: 1471-2202

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