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Table 3 Summary of furosemide effects on synaptic responses vs. anatomical location of stimulation site.

From: Slow GABAAmediated synaptic transmission in rat visual cortex

  control furosemide n
amplitude    
   basal 95 (71, 203) pA 39 (34, 66) pA 9
   apical 114 (73, 181) pA 28 (20, 58) pA 12
   distal 68 (60, 85) pA 113 (85, 133) pA 8
rise time    
   basal 2.8 (2.7, 4.5) ms 10.2 (6.9, 10.4) ms 9
   apical 3.3 (2.4, 4.1) ms 5.3 (4.1, 7.8) ms 12
   distal 6.6 (4.3, 9.2) ms 6.0 (5.1, 8.2) ms 8
decay time constant, τ1    
   basal 18.5 (13.5, 31.0) ms 47.2 (40.0, 73.0) ms 9
   apical 13.8 (12.5, 17.0) ms 31.1 (20.4, 34.7) ms 12
   distal 28.1 (21.6, 39.7) ms 39.3 (28.5, 59.5) ms 8
  1. Median values for control and furosemide groups are shown with the first and third quartiles indicated in parentheses. Stimulation sites were grouped according to their proximity to the basal (basal), proximal apical (apical), or the distal apical (distal) dendritic region of each pyramidal neuron. The decay time constants were estimated from the double exponential fits to the IPSC decaying response phase.