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Figure 7 | BMC Neuroscience

Figure 7

From: Slow GABAAmediated synaptic transmission in rat visual cortex

Figure 7

Effects of furosemide on evoked IPSCs based on anatomical origins of stimulation. Controls vs. furosemide treated (1 mM) conditions are shown in box plot form. Furosemide responses are shown in gray and control groups as open boxes. Evoked IPSC response amplitude, rise time and decay time constants are shown for stimulation of the basal (basal, n = 9), proximal apical (apical, n = 12) and distal apical (distal, n = 8) dendritic regions. Significance (p < 0.01) is indicated by ** (MANOVA and ANOVA factorial, see Table 4). Boxes span the first and third quartiles with medians indicated by thick center line and notch. A) Evoked IPSC amplitudes were reduced in the presence of furosemide compared to control for the stimulation sites in the region of the basal and proximal apical dendrites, but not the distal apical dendrites (see Table 3 for quantification). B) Rise time estimates were greater in the presence of furosemide for stimulation sites near the basal and proximal apical dendrites but not the distal apical dendrites. C) On average, the decay time constants (τ1) for evoked IPSCs were significantly greater with furosemide treatment than control conditions for stimulation sites near the basal dendrites. Decay time constants were not significantly different for responses evoked through stimulation of the distal apical dendrites in the presence of furosemide compared to control.

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