Skip to main content
Figure 3 | BMC Neuroscience

Figure 3

From: Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds

Figure 3

Average densities (± SEM) of FG-labeled surviving RGCs and ED1+ macrophages after inhibition of PI3K/akt and JAK/STAT pathways in Lewis rats. Significant decrease in RGC viability and concomitant increase in the number of macrophages were seen following PI3k/akt and JAK/STAT pathway inhibition (A). After macrophage removal (B), pathway inhibition-induced RGC loss was significantly but not completely prevented, indicating that both macrophage and the pathways were also involved in RGC viability in Lewis rats. Note that the numbers of surviving RGCs were significantly lower in Lewis than F344 rats. *p < 0.05, **p < 0.01 and ***p < 0.001 against DMSO group unless specified.

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us