Figure 9

The CEBPD network. (A) The differentially expressed genes from three models were constructed into an interaction network associated with CEBPD as a master regulated gene in PathwayArchitect. 152 genes with a high confidence index of direct and indirect interactions with CEBPD were included in the pathway. Connecting lines between gene symbols indicate interactions, the purple thick solid lines indicate the direct interactions between CEBPD and 7 genes, and they are GFAP, MBP, IGFBP5, FOS, CEBPB, CEBPA, ATF4 and HMOX1. Each of those genes connects to multiple functional genes highlighted with different color. Different types of interactions are denoted by symbols on the lines. Links scheme: Green square indicates regulation; arrow, direction of regulation; blue square with black border, binding; blue square, expression; orange circle, protein modification; green diamond with blue border, metabolism; green circle, promoter binding; light green triangle, transport; + in gray circle, positive effect; and – in gray circle, negative effect. (B) Temporal profile of CEBPD network in cerebellum of three models. Red nodes show gene expression level increase. Green nodes show gene expression decrease. Grey nodes present no significant change.