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Figure 3 | BMC Neuroscience

Figure 3

From: Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

Figure 3

Neuronal degeneration in brain. (A) Paraffin sections were stained with a neuron marker, NeuN, and a Purkinje cell marker, Calbindin D28K (calbindin). Progressive decreases in NeuN stained cells (upper panel) and incremental loss of Purkinje cells (lower panel) were shown in PS-NA mice at 12 wk and older. The NeuN changes were generalized, but regional variations in neuronal loss also were evident. (B) H&E stained paraffin sections of cerebellum showed the presence of Purkinje cells (arrows) in PS-/- (25 day) and WT (18 wk) mice and loss of Purkinje cells in PS-NA (18 wk) and 4L/PS-NA (18 wk) mice.

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