Figure 1From: Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient miceProgressive neurological deficits. (A, B) Narrow bridges. Mice were trained for three days. The latency to cross the bridge (A) and the number of foot slips (B) on a round wood beam (11 mm) were recorded (PS-NA, n = 10; WT, n = 10). PS-NA mice [open triangles] made significantly more foot slips and slower latency than WT [black squares] (*p < 0.05, **p < 0.01, ***p < 0.001). (C) Locomotor test at 18 wks. The mice were placed in an activity chamber for 120 min and locomotor activity was recorded in 5 min intervals (PS-NA, n = 5; WT, n = 5). PS-NA [open triangles] mice showed progressive failure to habituate compared to WT [black squares] mice.Back to article page