Figure 4

Edaravone ameliorated the amphetamine-induced rotational behavior of PD model of rats. Left graph: Rats receiving 250 mg/kg of edaravone infusion at 30 minutes after 6-OHDA lesion showed a significant reduction of the rotational number, although 30 and 100 mg/kg of edaravone did not exert significant effects. Data are shown as the mean rotational number per minute ± S.E. *p < 0.05 vs. rats receiving 30 mg/kg of edaravone and those without edaravone-administration. Right column: Edaravone administration (250 and 100 mg/kg) at 24 hours after 6-OHDA lesion significantly suppressed the rotational behavior, compared to rats receiving saline. Data are shown as the mean rotational number per minute ± S.E. *p < 0.05 vs. rats receiving 30 mg/kg of edaravone and those without edaravone-administration.