Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice

BMC Neuroscience

Table 1 Summary of SNP polymorphisms between DBA/2J and BALB/c mice, affecting coding regions of genes and ESTs in the Rgcs1 locus

Gene Name	DBA/2J	AA	BALB/c	AA	Position	Conserved*	Strain Cluster^†
Tlr1	C	Q	T	R	667	No	Possible
Tlr1	G	L	A	P	246	No	Possible
Tlr1	G	L	A	S	111	No	No
Tlr6	T	V	C	I	681	Yes	Yes
9130005N14Rik	G	T	A	A	498	No	No
Recc1	C	N	T	S	588	Yes	No
Klb	T	T	C	M	511	No	No
B3bp	A	S	G	G	1626	No	No
EG545758	A	S	G	L	141	No	No
Npal1	G	H	A	R	178/197	Yes	No
BC031901	C	G	T	E	432	No	No
BC031901	A	R	C	L	398	No	No
EG627807	T	S	C	N	44	Yes	No
Rest	A	G	G	S	555	No	No
EG384187	C	E	G	Q	67	No	No
EG384187	G	V	T	G	91	Yes	No
EG384187	T	K	A	N	144	No	No
EG384187	G	V	T	G	160	Yes	No
EG384187	T	T	C	I	164	No	No
Ugt2b1	G	L	A	F	425	No	No
Ugt2a3	T	T	G	P	508	No	Possible
Ugt2a2	G	A	T	E	500	No	N/A
Ugt2a2	C	R	G	G	467	No	Yes
C230008H04Rik	C	K	T	E	37	No	No
Slc10a6	C	T	T	A	2	No	No
Klhl8	T	R	C	Q	18	No	No
Sparcl1	G	R	A	Q	384	No	Possible
Zfp326	G	G	A	D	493	No	Possible
Zfp644	C	N	T	S	210	Yes	No
4921521K07Rik	A	I	G	V	102	Yes	Possible
4921521K07Rik	T	F	A	Y	280	Yes	No
A830010M20Rik	G	D	A	N	382/630	No	No
A830010M20Rik	G	S	A	N	762/1010	Yes	Possible
AW060207	G	D	A	G	279	No	Possible
AW060207	G	H	C	Q	355	Yes	No
Pigg	G	V	A	I	132	Yes	No

*Conservative vs Non-conservative amino acids (AA) were assigned based on differences in charge and hydrophobicity. †Strain clustering refers to data showing the same SNP in at least one reference mouse strain with a similar quantitative phenotype. A score of No indicates a DBA/2J or BALB/c polymorphism in at least one conflicting reference strain. A score of Possible indicates polymorphisms that fit trend for intermediate strains, but for which there is limited data for reference strains, or where there is data only for one set of reference strains. Reference strains examined were 129X1/SVJ and C57Bl/6J for DBA/2J mice, and NOD/LtJ and C3H/HeJ for BALB/cByJ mice. Intermediate strains were A/J and NZB/BINJ [20].

ISSN: 1471-2202